Pluronic nanoparticles do not modulate immune responses mounted by macrophages
- Authors
- Kim, Hyun Gyung; Jo, Sang-Hyun; Yeon, Seung-min; Kim, Kyong Hoon; Chung, Jin Woong; Park, Tae Won; Byun, Youngjoo; Lee, Eun Hee; Park, Young In; Jung, Yong Woo
- Issue Date
- Dec-2013
- Publisher
- POLYMER SOC KOREA
- Keywords
- pluronic nanoparticles; lipopolysaccharides; macrophage; nitric oxide; proinflammatory cytokines
- Citation
- MACROMOLECULAR RESEARCH, v.21, no.12, pp.1355 - 1359
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MACROMOLECULAR RESEARCH
- Volume
- 21
- Number
- 12
- Start Page
- 1355
- End Page
- 1359
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101415
- DOI
- 10.1007/s13233-013-1174-7
- ISSN
- 1598-5032
- Abstract
- Nanomaterials have been developed for the target delivery of medicine because they show the characteristics of selective emission or controlled release. Although accumulated data suggest the efficacy of these materials for the target delivery, it still remains to be determined whether they modulate immune responses to pathogens or foreign materials. In this study, we examined whether Pluronic nanoparticles (NPs), a type of nanomaterial, alter immune responses mediated by macrophages. When RAW 264.7 cells (RAW cells) were treated with Pluronic NPs in the presence or absence of lipopolysaccharides (LPS), they produced normal levels of nitric oxide (NO). Furthermore, the treatment with Pluronic nanomaterials did not induce cytotoxicity with or without LPS. Further, LPS-stimulated RAW cells expressed comparable levels of proinflammatory cytokine genes, such as interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha, with or without treatment by Pluronic NPs. These data suggest that Pluronic NPs do not modulate immune responses mediated by macrophages.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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