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Comparison of whole blood collection and double-unit erythrocytapheresis in preoperative autologous blood donation

Authors
Kim, MiyoungKim, Hyung SukKim, Yang HyunChoi, Ji SeonYang, Hoon JooHwang, Soon JungKim, Myung JinLee, Jong HoChoi, Jin YoungHan, Kyou-Sup
Issue Date
Dec-2013
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Preoperative autologous blood donation; Erythrocytapheresis; Apheresis
Citation
TRANSFUSION AND APHERESIS SCIENCE, v.49, no.3, pp.542 - 547
Indexed
SCIE
SCOPUS
Journal Title
TRANSFUSION AND APHERESIS SCIENCE
Volume
49
Number
3
Start Page
542
End Page
547
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101532
DOI
10.1016/j.transci.2013.09.015
ISSN
1473-0502
Abstract
Introduction: We compared preoperative autologous blood donation (PABD) using serial manual whole blood (WB) and PABD using a single session, double-unit erythrocytapheresis in terms of the hemodynamic recovery and clinical outcomes. Materials and methods: This study included 56 donors in the WB PABD group and 117 donors in the double-unit erythrocytapheresis PABD group. All subjects were men with body weight >70 kg, Hb level >13.3 g/dL, Hct >40%, and who were scheduled for oral and maxillofacial surgery. Three cycles of manual WB collection for PABD or a single session, double-unit erythrocytapheresis using the Alyx was performed. Results: There were no significant differences in donor demographic variables including age, height, weight, Hb, Hct, or red cell mass between the 2 groups. The double-unit erythrocytapheresis was completed earlier than the last manual WB PABD (at 15.3 +/- 4.7 days and 6.5 +/- 3.2 days before surgery, p < 0.001). Hct values before surgery were higher in the double-unit erythrocytapheresis PABD group than in the manual WB PABD group (39.7 +/- 3.2 vs. 38.6 +/- 2.7, p = 0.024). Delta Hct and %Delta Hct before the first PABD and before surgery were lower in the double-unit erythrocytapheresis PABD group than in the manual WE PABD group (-5.6 +/- 2.8 vs. -6.8 +/- 2.7, p = 0.010 and -12.3 +/- 5.9 vs. -14.8 +/- 5.6, p = 0.008, respectively). The incidence of additional allogeneic blood transfusions during or after surgery and the post-operative Hb and Hct values were similar in the 2 groups. The length of hospital stay after surgery was significantly longer in the manual WB PABD group than in the double-unit erythrocytapheresis group (6.1 +/- 2.5 vs. 5.4 +/- 1.9, p = 0.043). Of the 33 donors in the double-unit erythrocytapheresis PABD group, 7 (21.2%) reported discomforts related to the procedure, and 6 graded the discomforts (hypocalcemia, perioral tingling sense, paresthesia, dizziness, stuffiness, pain on the intravenous site, and muscle tension) as mild. Conclusion: The single session, double-unit erythrocytapheresis prolonged the time interval between PABD and surgery and led to better hemodynamic recovery than the serial manual WE PABD, and hypocalcemic symptoms were mild. (C) 2013 Elsevier Ltd. All rights reserved.
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