Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast
- Authors
- Choi, Kyung-Mi; Lee, Hye-Lan; Kwon, Young-Yon; Kang, Mi-Sun; Lee, Sung-Keun; Lee, Cheol-Koo
- Issue Date
- 8-Nov-2013
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Caloric restriction; Caloric restriction mimetics; Rapamycin; Reactive oxygen species; Mitochondrial membrane potential; ATP
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.441, no.1, pp.236 - 242
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 441
- Number
- 1
- Start Page
- 236
- End Page
- 242
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101622
- DOI
- 10.1016/j.bbrc.2013.10.049
- ISSN
- 0006-291X
- Abstract
- Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process. (C) 2013 Elsevier Inc. All rights reserved.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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