UVB Induces HIF-1 alpha-Dependent TSLP Expression via the JNK and ERK Pathways
DC Field | Value | Language |
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dc.contributor.author | Jang, Yeonsue | - |
dc.contributor.author | Jeong, Sang H. | - |
dc.contributor.author | Park, Yoon-Hee | - |
dc.contributor.author | Bae, Hyun C. | - |
dc.contributor.author | Lee, Hana | - |
dc.contributor.author | Ryu, Woo-In | - |
dc.contributor.author | Park, Gil H. | - |
dc.contributor.author | Son, Sang W. | - |
dc.date.accessioned | 2021-09-05T19:28:59Z | - |
dc.date.available | 2021-09-05T19:28:59Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101671 | - |
dc.description.abstract | Thymic stromal lymphopoietin (TSLP) may have a key role in the initiation and maintenance of allergic inflammatory diseases, including atopic dermatitis. The present study revealed that UVB radiation exposure could induce TSLP expression in human keratinocytes and a human skin equivalent model. In addition, we investigated the regulatory mechanism of UVB-induced TSLP expression in keratinocytes. TSLP expression was upregulated by transfection with pcDNA3-hypoxia-inducible factor (HIF)-1 alpha (P402A and P564A), which stably expresses HIF-1 alpha protein. UVB-induced TSLP induction in keratinocytes was suppressed in the treatment of mitogen-activated protein kinase inhibitors or small interfering RNAs against HIF-1 alpha. The results of chromatin immunoprecipitation assays indicate the direct involvement of HIF-1 alpha in UVB-mediated TSLP induction. Taken together, these findings indicate that UVB exposure may increase TSLP expression through a HIF-1 alpha-dependent mechanism via the c-JUN N-terminal kinase and extracellular signal-regulated kinase pathways in human keratinocytes. Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2-attracting chemokine (c-c motif) ligand 17 by human dendritic cells. The present study suggests an important role of HIF-1 alpha in UVB-mediated immune response in keratinocytes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | THYMIC STROMAL LYMPHOPOIETIN | - |
dc.subject | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | - |
dc.subject | HUMAN EPITHELIAL-CELLS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ALLERGIC INFLAMMATION | - |
dc.subject | DEPENDENT PATHWAY | - |
dc.subject | NARROW-BAND | - |
dc.subject | RADIATION | - |
dc.subject | IRRADIATION | - |
dc.subject | ACTIVATION | - |
dc.title | UVB Induces HIF-1 alpha-Dependent TSLP Expression via the JNK and ERK Pathways | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Gil H. | - |
dc.contributor.affiliatedAuthor | Son, Sang W. | - |
dc.identifier.doi | 10.1038/jid.2013.203 | - |
dc.identifier.scopusid | 2-s2.0-84885960640 | - |
dc.identifier.wosid | 000325807800017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INVESTIGATIVE DERMATOLOGY, v.133, no.11, pp.2601 - 2608 | - |
dc.relation.isPartOf | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.citation.title | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.citation.volume | 133 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2601 | - |
dc.citation.endPage | 2608 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | THYMIC STROMAL LYMPHOPOIETIN | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | - |
dc.subject.keywordPlus | HUMAN EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ALLERGIC INFLAMMATION | - |
dc.subject.keywordPlus | DEPENDENT PATHWAY | - |
dc.subject.keywordPlus | NARROW-BAND | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | IRRADIATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
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