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Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Jae Yeon | - |
| dc.contributor.author | Lee, Hwanbum | - |
| dc.contributor.author | Oh, Keun Sang | - |
| dc.contributor.author | Kweon, Seho | - |
| dc.contributor.author | Jeon, Ok-cheol | - |
| dc.contributor.author | Byun, Youngro | - |
| dc.contributor.author | Kim, Kwangmeyung | - |
| dc.contributor.author | Kwon, Ick Chan | - |
| dc.contributor.author | Kim, Sang Yoon | - |
| dc.contributor.author | Yuk, Soon Hong | - |
| dc.date.accessioned | 2021-09-05T19:37:11Z | - |
| dc.date.available | 2021-09-05T19:37:11Z | - |
| dc.date.created | 2021-06-15 | - |
| dc.date.issued | 2013-11 | - |
| dc.identifier.issn | 0142-9612 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101720 | - |
| dc.description.abstract | A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro-in vivo correlation was discussed in relation to manipulation of the NP structures. (C) 2013 Elsevier Ltd. All rights reserved. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | ELSEVIER SCI LTD | - |
| dc.subject | DRUG-DELIVERY | - |
| dc.subject | CORE/SHELL NANOPARTICLES | - |
| dc.subject | LIPOSOME FUSION | - |
| dc.subject | VESICLE FUSION | - |
| dc.subject | EXENDIN-4 | - |
| dc.subject | CAPSULES | - |
| dc.subject | BILAYER | - |
| dc.subject | RECEPTOR | - |
| dc.subject | CORE | - |
| dc.title | Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Oh, Keun Sang | - |
| dc.contributor.affiliatedAuthor | Kwon, Ick Chan | - |
| dc.contributor.affiliatedAuthor | Yuk, Soon Hong | - |
| dc.identifier.doi | 10.1016/j.biomaterials.2013.07.040 | - |
| dc.identifier.scopusid | 2-s2.0-84881663280 | - |
| dc.identifier.wosid | 000324720700044 | - |
| dc.identifier.bibliographicCitation | BIOMATERIALS, v.34, no.33, pp.8444 - 8449 | - |
| dc.relation.isPartOf | BIOMATERIALS | - |
| dc.citation.title | BIOMATERIALS | - |
| dc.citation.volume | 34 | - |
| dc.citation.number | 33 | - |
| dc.citation.startPage | 8444 | - |
| dc.citation.endPage | 8449 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Engineering | - |
| dc.relation.journalResearchArea | Materials Science | - |
| dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
| dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
| dc.subject.keywordPlus | DRUG-DELIVERY | - |
| dc.subject.keywordPlus | CORE/SHELL NANOPARTICLES | - |
| dc.subject.keywordPlus | LIPOSOME FUSION | - |
| dc.subject.keywordPlus | VESICLE FUSION | - |
| dc.subject.keywordPlus | EXENDIN-4 | - |
| dc.subject.keywordPlus | CAPSULES | - |
| dc.subject.keywordPlus | BILAYER | - |
| dc.subject.keywordPlus | RECEPTOR | - |
| dc.subject.keywordPlus | CORE | - |
| dc.subject.keywordAuthor | Core/shell nanoparticles | - |
| dc.subject.keywordAuthor | Layer-by-layer approach | - |
| dc.subject.keywordAuthor | Pluronics | - |
| dc.subject.keywordAuthor | Lipid bilayers | - |
| dc.subject.keywordAuthor | Sustained delivery of exenatide | - |
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