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Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Authors
Kim, Jae YeonLee, HwanbumOh, Keun SangKweon, SehoJeon, Ok-cheolByun, YoungroKim, KwangmeyungKwon, Ick ChanKim, Sang YoonYuk, Soon Hong
Issue Date
11월-2013
Publisher
ELSEVIER SCI LTD
Keywords
Core/shell nanoparticles; Layer-by-layer approach; Pluronics; Lipid bilayers; Sustained delivery of exenatide
Citation
BIOMATERIALS, v.34, no.33, pp.8444 - 8449
Indexed
SCIE
SCOPUS
Journal Title
BIOMATERIALS
Volume
34
Number
33
Start Page
8444
End Page
8449
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101720
DOI
10.1016/j.biomaterials.2013.07.040
ISSN
0142-9612
Abstract
A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro-in vivo correlation was discussed in relation to manipulation of the NP structures. (C) 2013 Elsevier Ltd. All rights reserved.
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