Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Human cytomegalovirus (HCMV) US2 protein interacts with human CD1d (hCD1d) and down-regulates invariant NKT (iNKT) cell activity

Authors
Han, JihyeRho, Seung BaeLee, Jae YeonBae, JoonbeomPark, Se HoLee, Suk JunLee, Sang YeolAhn, CurieKim, Jae YoungChun, Taehoon
Issue Date
11월-2013
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Keywords
Antigen presentation; HCMV US2 protein; Human CD1d; Human cytomegalovirus; Invariant NKT cell
Citation
MOLECULES AND CELLS, v.36, no.5, pp.455 - 464
Indexed
SCIE
SCOPUS
KCI
Journal Title
MOLECULES AND CELLS
Volume
36
Number
5
Start Page
455
End Page
464
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101795
DOI
10.1007/s10059-013-0221-8
ISSN
1016-8478
Abstract
To avoid host immune surveillance, human cytomegalovirus (HCMV) encoded endoplasmic reticulum (ER)-membrane glycoprotein US2, which interferes with antigen presenting mechanism of Major histocompatibility complex (MHC) class Ia and class II molecules. However, not many attempts have been made to study the effect of HCMV US2 on the expression of MHC class Ib molecules. In this study, we examined the effect of HCMV US2 on the expression and function of human CD1d (hCD1d), which presents glycolipid antigens to invariant NKT (iNKT) cells. Our results clearly showed that the physiological interaction between ER lumenal domain of HCMV US2 and alpha 3 domain of hCD1d was observed within ER. Compared with mature form of hCD1d, immature form of hCD1d is more susceptible to ubiquitin-dependent proteasomal degradation mediated by HCMV US2. Moreover, the ectopic expression of HCMV US2 leads to the down-modulation of iNKT cell activity without significant change of hCD1d expression. These results will advance our understanding of the function of HCMV US2 in immune evasive mechanisms against anti-viral immunity of iNKT cells.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Life Sciences > 1. Journal Articles
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Chun, Tae hoon photo

Chun, Tae hoon
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE