Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung-Yup | - |
dc.contributor.author | Lee, Soo-Jung | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Patkar, Ashwin A. | - |
dc.contributor.author | Masand, Prakash S. | - |
dc.contributor.author | Pae, Chi-Un | - |
dc.date.accessioned | 2021-09-05T20:23:06Z | - |
dc.date.available | 2021-09-05T20:23:06Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-10-01 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101914 | - |
dc.description.abstract | The brain is an organ predisposed to oxidative/nitrosative stress. This is especially true in the case of aging as well as several neurodegenerative diseases. Under such circumstances, a decline in the normal antioxidant defense mechanisms leads to an increase in the vulnerability of the brain to the deleterious effects of oxidative damage. Highly reactive oxygen/nitrogen species damage lipids, proteins, and mitochondrial and neuronal genes. Unless antioxidant defenses react appropriately to damage inflicted by radicals, neurons may experience microalteration, microdysfunction, and degeneration. We reviewed how oxidative and nitrosative stresses contribute to the pathogenesis of depressive disorders and reviewed the clinical implications of various antioxidants as future targets for antidepressant treatment. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | MAJOR DEPRESSIVE DISORDER | - |
dc.subject | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject | CHEMOATTRACTANT PROTEIN-1 MCP1 | - |
dc.subject | ANTIOXIDANT ENZYME-ACTIVITIES | - |
dc.subject | HEME OXYGENASE-1 EXPRESSION | - |
dc.subject | SUPEROXIDE-DISMUTASE LEVELS | - |
dc.subject | GLYCOGEN-SYNTHASE KINASE-3 | - |
dc.subject | KILLER-CELL CYTOTOXICITY | - |
dc.subject | INDUCED OXIDATIVE STRESS | - |
dc.subject | NF-KAPPA-B | - |
dc.title | Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Changsu | - |
dc.identifier.doi | 10.1016/j.pnpbp.2012.09.008 | - |
dc.identifier.scopusid | 2-s2.0-84883554467 | - |
dc.identifier.wosid | 000324480900033 | - |
dc.identifier.bibliographicCitation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.46, pp.224 - 235 | - |
dc.relation.isPartOf | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.title | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.volume | 46 | - |
dc.citation.startPage | 224 | - |
dc.citation.endPage | 235 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | MAJOR DEPRESSIVE DISORDER | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | CHEMOATTRACTANT PROTEIN-1 MCP1 | - |
dc.subject.keywordPlus | ANTIOXIDANT ENZYME-ACTIVITIES | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 EXPRESSION | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE LEVELS | - |
dc.subject.keywordPlus | GLYCOGEN-SYNTHASE KINASE-3 | - |
dc.subject.keywordPlus | KILLER-CELL CYTOTOXICITY | - |
dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordAuthor | Antidepressant | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Novel target | - |
dc.subject.keywordAuthor | Oxidative/nitrosative stress | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.