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Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants

Authors
Lee, Seung-YupLee, Soo-JungHan, ChangsuPatkar, Ashwin A.Masand, Prakash S.Pae, Chi-Un
Issue Date
1-10월-2013
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Antidepressant; Depression; Novel target; Oxidative/nitrosative stress
Citation
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.46, pp.224 - 235
Indexed
SCIE
SCOPUS
Journal Title
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume
46
Start Page
224
End Page
235
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101914
DOI
10.1016/j.pnpbp.2012.09.008
ISSN
0278-5846
Abstract
The brain is an organ predisposed to oxidative/nitrosative stress. This is especially true in the case of aging as well as several neurodegenerative diseases. Under such circumstances, a decline in the normal antioxidant defense mechanisms leads to an increase in the vulnerability of the brain to the deleterious effects of oxidative damage. Highly reactive oxygen/nitrogen species damage lipids, proteins, and mitochondrial and neuronal genes. Unless antioxidant defenses react appropriately to damage inflicted by radicals, neurons may experience microalteration, microdysfunction, and degeneration. We reviewed how oxidative and nitrosative stresses contribute to the pathogenesis of depressive disorders and reviewed the clinical implications of various antioxidants as future targets for antidepressant treatment. (C) 2012 Elsevier Inc. All rights reserved.
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