Effect of hyaluronic acid (HA) in a HA/PLGA scaffold on annulus fibrosus regeneration: In vivo tests
DC Field | Value | Language |
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dc.contributor.author | Song, Jeong Eun | - |
dc.contributor.author | Kim, Min Jeong | - |
dc.contributor.author | Yoon, Hyeon | - |
dc.contributor.author | Yoo, Hanna | - |
dc.contributor.author | Lee, Yu Jeong | - |
dc.contributor.author | Kim, Ha Neul | - |
dc.contributor.author | Lee, Dongwon | - |
dc.contributor.author | Yuk, Soon Hong | - |
dc.contributor.author | Khang, Gilson | - |
dc.date.accessioned | 2021-09-05T20:35:24Z | - |
dc.date.available | 2021-09-05T20:35:24Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/101981 | - |
dc.description.abstract | Intervertebral disc (IVD) degeneration is an age-related process that affects the biomechanical properties of the spine and is assumed to be one of the principal causes of low back pain. Poly(lactide-co-glycolide) (PLGA) and hyaluronic acid (HA) have been widely used as biocompatible scaffold materials for tissue regeneration. In the present study, we fabricated a microporous PLGA scaffold by the salt-leaching method and HA-loaded PLGA scaffolds by the penetrating method. As the porosity of PLGA and PLGA/HA is 90.7% and 96.5%, respectively, PLGA/HA scaffold has the higher porosity. However, the pore size of PLGA (240.7 +/- 14.0 mu m) is the larger than HA/PLGA (212.0 +/- 12.5 mu m), and cells from the annulus fibrosus (AF) were seeded into the scaffolds. For the in vivo study, the PLGA and HA/PLGA scaffolds were implanted in four-week-old nude mice. All scaffolds were characterized using a scanning electron microscope (SEM), and the amounts of glycosaminoglycan (GAG) and collagen in the scaffolds were determined by a spectrophotometer. Histological evaluation indicated the higher level of AF cell proliferation in the HA/PLGA scaffold than in PLGA scaffolds alone. In addition, AF cells showed the stronger production of GAG and collagen in HA/PLGA. Our results indicate that the HA/PLGA scaffold might be useful for intervertebral disc regeneration. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | POLYMER SOC KOREA | - |
dc.subject | TISSUE | - |
dc.subject | VITRO | - |
dc.subject | SUBMUCOSA | - |
dc.subject | REPAIR | - |
dc.subject | CELLS | - |
dc.title | Effect of hyaluronic acid (HA) in a HA/PLGA scaffold on annulus fibrosus regeneration: In vivo tests | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yuk, Soon Hong | - |
dc.identifier.doi | 10.1007/s13233-013-1137-z | - |
dc.identifier.scopusid | 2-s2.0-84881311133 | - |
dc.identifier.wosid | 000322582600005 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, v.21, no.10, pp.1075 - 1082 | - |
dc.relation.isPartOf | MACROMOLECULAR RESEARCH | - |
dc.citation.title | MACROMOLECULAR RESEARCH | - |
dc.citation.volume | 21 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1075 | - |
dc.citation.endPage | 1082 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001812496 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | SUBMUCOSA | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | poly(lactide-co-glycolide) (PLGA) | - |
dc.subject.keywordAuthor | hyaluronic acid (HA) | - |
dc.subject.keywordAuthor | annulus fibrosus | - |
dc.subject.keywordAuthor | in vivo | - |
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