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A Lipoprotein Lipase Gene Polymorphism Interacts with Consumption of Alcohol and Unsaturated Fat to Modulate Serum HDL-Cholesterol Concentrations

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dc.contributor.authorBaik, Inkyung-
dc.contributor.authorLee, SeungKu-
dc.contributor.authorKim, Seong Hwan-
dc.contributor.authorShin, Chol-
dc.date.accessioned2021-09-05T20:42:41Z-
dc.date.available2021-09-05T20:42:41Z-
dc.date.created2021-06-15-
dc.date.issued2013-10-
dc.identifier.issn0022-3166-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/102021-
dc.description.abstractThere are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genome-wide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447x) mutation (D' = 0.99) of LPL. We found that carrying the T allele reflecting the LPL x447 allele was positively associated with follow-up measurement of HDL-C concentrations (P < 0.001). In the linear regression model adjusted for baseline HDL-C concentration and potential risk factors, we observed interactive effects of the polymorphism and consumption of alcohol (P-interaction < 0.01) and unsaturated fat (P-interaction <0.05) on follow-up measurement of HDL-C concentrations. We also observed interactive effects of the polymorphism and body mass index (P-interaction < 0.01) on follow-up measurement of TG concentrations after adjusting for the baseline level and potential risk factors. Our findings suggest that carriers of the LPL X 447 allele benefit from moderate alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL x447 allele need to control body weight to prevent hypertriglyceridemia.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherOXFORD UNIV PRESS-
dc.subjectHIGH-DENSITY-LIPOPROTEIN-
dc.subjectGENOME-WIDE ASSOCIATION-
dc.subjectCORONARY-HEART-DISEASE-
dc.subjectAPOLIPOPROTEIN-A-I-
dc.subjectBLOOD CHOLESTEROL-
dc.subjectPHYSICAL-ACTIVITY-
dc.subjectLIPID-LEVELS-
dc.subjectBODY-FAT-
dc.subjectLPL GENE-
dc.subjectRISK-
dc.titleA Lipoprotein Lipase Gene Polymorphism Interacts with Consumption of Alcohol and Unsaturated Fat to Modulate Serum HDL-Cholesterol Concentrations-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Seong Hwan-
dc.contributor.affiliatedAuthorShin, Chol-
dc.identifier.doi10.3945/jn.113.175315-
dc.identifier.scopusid2-s2.0-84885701161-
dc.identifier.wosid000330331700012-
dc.identifier.bibliographicCitationJOURNAL OF NUTRITION, v.143, no.10, pp.1618 - 1625-
dc.relation.isPartOfJOURNAL OF NUTRITION-
dc.citation.titleJOURNAL OF NUTRITION-
dc.citation.volume143-
dc.citation.number10-
dc.citation.startPage1618-
dc.citation.endPage1625-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNutrition & Dietetics-
dc.relation.journalWebOfScienceCategoryNutrition & Dietetics-
dc.subject.keywordPlusHIGH-DENSITY-LIPOPROTEIN-
dc.subject.keywordPlusGENOME-WIDE ASSOCIATION-
dc.subject.keywordPlusCORONARY-HEART-DISEASE-
dc.subject.keywordPlusAPOLIPOPROTEIN-A-I-
dc.subject.keywordPlusBLOOD CHOLESTEROL-
dc.subject.keywordPlusPHYSICAL-ACTIVITY-
dc.subject.keywordPlusLIPID-LEVELS-
dc.subject.keywordPlusBODY-FAT-
dc.subject.keywordPlusLPL GENE-
dc.subject.keywordPlusRISK-
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