A Lipoprotein Lipase Gene Polymorphism Interacts with Consumption of Alcohol and Unsaturated Fat to Modulate Serum HDL-Cholesterol Concentrations
- Authors
- Baik, Inkyung; Lee, SeungKu; Kim, Seong Hwan; Shin, Chol
- Issue Date
- 10월-2013
- Publisher
- OXFORD UNIV PRESS
- Citation
- JOURNAL OF NUTRITION, v.143, no.10, pp.1618 - 1625
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NUTRITION
- Volume
- 143
- Number
- 10
- Start Page
- 1618
- End Page
- 1625
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102021
- DOI
- 10.3945/jn.113.175315
- ISSN
- 0022-3166
- Abstract
- There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genome-wide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447x) mutation (D' = 0.99) of LPL. We found that carrying the T allele reflecting the LPL x447 allele was positively associated with follow-up measurement of HDL-C concentrations (P < 0.001). In the linear regression model adjusted for baseline HDL-C concentration and potential risk factors, we observed interactive effects of the polymorphism and consumption of alcohol (P-interaction < 0.01) and unsaturated fat (P-interaction <0.05) on follow-up measurement of HDL-C concentrations. We also observed interactive effects of the polymorphism and body mass index (P-interaction < 0.01) on follow-up measurement of TG concentrations after adjusting for the baseline level and potential risk factors. Our findings suggest that carriers of the LPL X 447 allele benefit from moderate alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL x447 allele need to control body weight to prevent hypertriglyceridemia.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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