Sex Differences in Hippocampal Neuronal Sensitization by Nicotine in M-gerbils
- Authors
- Hur, Young-Na; Lee, Joon; Sohn, Seung-Chan; Won, Chung-Gil; Lee, Hyung-Ha; Kim, Dong-Hoon; Choi, Sang-Hyun; Shin, Kyung-Ho; Chun, Boe-Gwun
- Issue Date
- 10월-2013
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Connexin; Evoked population spike; Hippocampus; Nicotine; Sex difference
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.17, no.5, pp.405 - 409
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 17
- Number
- 5
- Start Page
- 405
- End Page
- 409
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102047
- DOI
- 10.4196/kjpp.2013.17.5.405
- ISSN
- 1226-4512
- Abstract
- We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5 mg/kg: NT-0.5) slightly reduced ePSA in males but markedly augmented that in females. Acute NT (5.0 mg/kg) markedly increased the ePSA in all gerbils. Unlike acute NT-0.5, repeated NT-0.5 injection (twice a day for 7 days) significantly increased the ePSA in males and slightly affected the NT-0.5 effect in females. The Cx36 and Cx43 expression levels as well as Cx expressing neuronal populations were significantly increased by repeated NT-0.5 in in both male and female gerbils, and particularly, Cx43 expression was somewhat prominent in females. These results demonstrated a sex difference with respect to the nicotine effect on hippocampal bisynaptic excitability, irrelevant to connexin expression.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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