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Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis
- Issue Date
- 9월-2013
- Publisher
- BENTHAM SCIENCE PUBL LTD
- Keywords
- Antitumor efficacy; cancer targetability; chitosan/heparin composite; core/shell nanoparticles; enhanced permeability and retention effect; layer-by-layer approach; molecular imaging agent; Pluornics; Pluronic/liposome composite nanoparticles; polyethylene glycol; protein drug; self-assembly; temperature-induced phase transition; vesicle fusion
- Citation
- CURRENT MEDICINAL CHEMISTRY, v.20, no.28, pp.3488 - 3499
- Indexed
- SCIE
SCOPUS
- Journal Title
- CURRENT MEDICINAL CHEMISTRY
- Volume
- 20
- Number
- 28
- Start Page
- 3488
- End Page
- 3499
- ISSN
- 0929-8673
- Abstract
- Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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