Association between functional Fc receptor-like 3 (FCRL3)-169 C/T polymorphism and susceptibility to seropositive rheumatoid arthritis in Asians: A meta-analysis
- Authors
- Song, Gwan Gyu; Bae, Sang-Cheol; Kim, Jae-Hoon; Kim, Young Ho; Choi, Sung Jae; Ji, Jong Dae; Lee, Young Ho
- Issue Date
- 9월-2013
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- HUMAN IMMUNOLOGY, v.74, no.9, pp.1206 - 1213
- Indexed
- SCIE
SCOPUS
- Journal Title
- HUMAN IMMUNOLOGY
- Volume
- 74
- Number
- 9
- Start Page
- 1206
- End Page
- 1213
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102258
- DOI
- 10.1016/j.humimm.2013.05.018
- ISSN
- 0198-8859
- Abstract
- Objective: The aim of this study was to determine whether the functional Fc receptor like-3 (FCRL3) -169 C/T polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods: A meta-analysis was conducted on the associations between the FCRL3 169 C/T polymorphism and RA. Results: A total of 17 comparison studies including 11,170 patients and 11,142 controls were considered in the meta-analysis. The meta-analysis showed no association between RA and the FCRL3 169 C allele in study subjects (OR = 1.046, 95% CI = 0.997-1.098, p = 0.068). Stratification by ethnicity indicated an association between the FCRL3 169 C allele and RA in Asians (OR = 1.101, 95% CI = 1.035-1.174, p = 0.002), but not in Europeans. Stratification of patients according to the presence of rheumatoid factor (RF) revealed a different significant association between the C allele and RA in RF-positive and RF-negative RA patients. Stratification by ethnicity indicated an association between the FCRL3 -169 C allele and RF-positive RA in Asians (OR = 1.093, 95% CI = 1.004-1.189, p = 0.040), but not in Europeans. Conclusions: This meta-analysis demonstrates that the FCRL3 169 C/T polymorphism may confer susceptibility to seropositive RA in Asians. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.