Higher mortality in metabolically obese normal-weight people than in metabolically healthy obese subjects in elderly Koreans
- Authors
- Choi, Kyung Mook; Cho, Hyun Joo; Choi, Hae Yoon; Yang, Sae Jeong; Yoo, Hye Jin; Seo, Ji A.; Kim, Sin Gon; Baik, Sei Hyun; Choi, Dong Seop; Kim, Nan Hee
- Issue Date
- 9월-2013
- Publisher
- WILEY-BLACKWELL
- Citation
- CLINICAL ENDOCRINOLOGY, v.79, no.3, pp.364 - 370
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL ENDOCRINOLOGY
- Volume
- 79
- Number
- 3
- Start Page
- 364
- End Page
- 370
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102337
- DOI
- 10.1111/cen.12154
- ISSN
- 0300-0664
- Abstract
- Objective The purpose of this study was to investigate the impact of body mass index (BMI) and the presence of metabolic syndrome (MetS) on all-cause and cardiovascular mortality in elderly Korean men and women, and especially to compare metabolically obese normal-weight (MONW) and metabolically healthy obese (MHO) subjects. Patients and methods A total of 2317 elderly people (over 60 years of age) were studied using follow-up data from the South-West Seoul (SWS) Study, a prospective cohort study. Mortality from all causes and cardiovascular disease (CVD) were evaluated according to the combination of the presence or absence of MetS and Asian-specific body mass index (BMI) criteria (BMI <23 kg/m(2); normal weight, BMI 23-24.9 kg/m(2); overweight, BMI >= 25 kg/m(2); obesity). Results During a median follow-up of 10.3 years, 393 subjects died, including 126 from CVD. Among subjects with MetS, all-cause and CVD mortality were significantly higher in normal-weight subjects than overweight or obese individuals in Cox proportional-hazard models adjusted for confounding factors. Furthermore, among six groups with various MetS/BMI combinations, MONW individuals had the highest risk, whereas overweight subjects without MetS had the lowest risk of death from all causes and CVD [HR = 2.2 (95% CI = 1.4-3.4), HR = 3.0 (95% CI = 1.4-6.6) respectively]. Interestingly, all-cause mortality was significantly higher in MONW than MHO individuals. Conclusions In contrast to MHO subjects, elderly individuals with the MONW phenotype exhibited greater all-cause mortality during 10 years of follow-up.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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