Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents
DC Field | Value | Language |
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dc.contributor.author | Cho, Ig Jun | - |
dc.contributor.author | Lee, Chang Woo | - |
dc.contributor.author | Lee, Myeong Youl | - |
dc.contributor.author | Kang, Moo Rim | - |
dc.contributor.author | Yun, Jieun | - |
dc.contributor.author | Oh, Soo Jin | - |
dc.contributor.author | Han, Sang-Bae | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Park, Song-Kyu | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.contributor.author | Jung, Sang-Hun | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.date.accessioned | 2021-09-05T23:02:50Z | - |
dc.date.available | 2021-09-05T23:02:50Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102496 | - |
dc.description.abstract | In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammatory effect of S(+)-zaltoprofen was stronger than that of racemic zaltoprofen, suggesting that S(+)-zaltoprofen is an active component of racemic zaltoprofen in terms of anti-inflammatory activity. In contrast, the results of acetic acid-induced writhing model demonstrated that no significant analgesic effect was observed by racemic zaltoprofen and zaltoprofen enantiomers at doses used in carrageenan-induced paw edema model. However, racemic zaltoprofen and zaltoprofen enantiomers all exerted an analgesic effect at higher doses, which is inconsistent with the result of carrageenan-induced paw edema model. Gastric ulcers induced by racemic zaltoprofen and zaltoprofen enantiomers were minimal. Taken together, these results suggest that S(+)-zaltoprofen is a potent and active anti-inflammatory component of racemic zaltoprofen, but both S(+)-zaltoprofen and R(-)-zaltoprofen might seem to contribute to the analgesic effect of racemic zaltoprofen. (c) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | RESPIRATORY-TRACT INFECTION | - |
dc.subject | IBUPROFEN | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | DRUG | - |
dc.subject | DISPOSITION | - |
dc.subject | RESPONSES | - |
dc.subject | BLOCKING | - |
dc.subject | CHILDREN | - |
dc.subject | RATS | - |
dc.title | Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.contributor.affiliatedAuthor | Park, Song-Kyu | - |
dc.identifier.doi | 10.1016/j.intimp.2013.05.008 | - |
dc.identifier.scopusid | 2-s2.0-84878407761 | - |
dc.identifier.wosid | 000321537000008 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.16, no.4, pp.457 - 460 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 460 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | RESPIRATORY-TRACT INFECTION | - |
dc.subject.keywordPlus | IBUPROFEN | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | DISPOSITION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | BLOCKING | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Zaltoprofen | - |
dc.subject.keywordAuthor | Enantiomer | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | Analgesic | - |
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