Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents
- Authors
- Cho, Ig Jun; Lee, Chang Woo; Lee, Myeong Youl; Kang, Moo Rim; Yun, Jieun; Oh, Soo Jin; Han, Sang-Bae; Lee, Kiho; Park, Song-Kyu; Kim, Hwan Mook; Jung, Sang-Hun; Kang, Jong Soon
- Issue Date
- 8월-2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Zaltoprofen; Enantiomer; Anti-inflammatory; Analgesic
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.16, no.4, pp.457 - 460
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 16
- Number
- 4
- Start Page
- 457
- End Page
- 460
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102496
- DOI
- 10.1016/j.intimp.2013.05.008
- ISSN
- 1567-5769
- Abstract
- In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammatory effect of S(+)-zaltoprofen was stronger than that of racemic zaltoprofen, suggesting that S(+)-zaltoprofen is an active component of racemic zaltoprofen in terms of anti-inflammatory activity. In contrast, the results of acetic acid-induced writhing model demonstrated that no significant analgesic effect was observed by racemic zaltoprofen and zaltoprofen enantiomers at doses used in carrageenan-induced paw edema model. However, racemic zaltoprofen and zaltoprofen enantiomers all exerted an analgesic effect at higher doses, which is inconsistent with the result of carrageenan-induced paw edema model. Gastric ulcers induced by racemic zaltoprofen and zaltoprofen enantiomers were minimal. Taken together, these results suggest that S(+)-zaltoprofen is a potent and active anti-inflammatory component of racemic zaltoprofen, but both S(+)-zaltoprofen and R(-)-zaltoprofen might seem to contribute to the analgesic effect of racemic zaltoprofen. (c) 2013 Elsevier B.V. All rights reserved.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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