Longitudinal Lung Volume Changes in Patients with Chronic Obstructive Pulmonary Disease
- Authors
- Lee, Jae Seung; Kim, Seon Ok; Seo, Joon Beom; Lee, Ji-Hyun; Kim, Eun Kyung; Kim, Tae-Hyung; Kim, Woo Jin; Lee, Jin Hwa; Lee, Sang-Min; Lee, Sangyeub; Lim, Seong Yong; Shin, Tae Rim; Yoon, Ho Il; Lee, Sei Won; Huh, Jin Won; Oh, Yeon-Mok; Lee, Sang-Do
- Issue Date
- 8월-2013
- Publisher
- SPRINGER
- Keywords
- Chronic obstructive pulmonary disease; Spirometry; Lung volume measurements; Inspiratory capacity; Total lung capacity
- Citation
- LUNG, v.191, no.4, pp.405 - 412
- Indexed
- SCIE
SCOPUS
- Journal Title
- LUNG
- Volume
- 191
- Number
- 4
- Start Page
- 405
- End Page
- 412
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102558
- DOI
- 10.1007/s00408-013-9478-0
- ISSN
- 0341-2040
- Abstract
- The progression of lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD) has not been studied in a long-term prospective cohort. We explored the longitudinal changes in lung volume compartments with the aim of identifying predictors of a rapid decline of the inspiratory capacity to total lung capacity ratio (IC/TLC). The study population comprised 324 patients with COPD who were recruited prospectively. Annual rates of changes in pulmonary function, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), vital capacity (VC), IC, and IC/TLC, were estimated using the random coefficient models. The mean annual rates of changes in pre- and post-bronchodilator FEV1 were -23.0 mL/year (p < 0.001) and -26.5 mL/year (p = 0.004). The mean annual rates of changes in VC, IC, TLC, and IC/TLC were -33.7 mL/year (p = 0.007), -53.9 mL/year (p < 0.001), -43.7 mL/year (p = 0.012), and -0.65 %/year (p = 0.001), respectively. RV, FRC, and RV/TLC did not change significantly during the study period. Multivariate logistic regression analysis showed that a high modified Medical Research Council (MMRC) dyspnea scale score, a high Charlson comorbidity index value, and low post-bronchodilator FEV1 were associated with rapid decline in IC/TLC. MMRC dyspnea scale, post-bronchodilator FEV1, and the Charlson comorbidity index at baseline were independent predictors of a rapid decline in IC/TLC.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.