Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities
DC Field | Value | Language |
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dc.contributor.author | Cho, Namki | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Huh, Jungmoo | - |
dc.contributor.author | Choi, Ji Hoon | - |
dc.contributor.author | Yang, Heejung | - |
dc.contributor.author | Jeong, Eun Ju | - |
dc.contributor.author | Kim, Hong Pyo | - |
dc.contributor.author | Sung, Sang Hyun | - |
dc.date.accessioned | 2021-09-05T23:17:05Z | - |
dc.date.available | 2021-09-05T23:17:05Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102581 | - |
dc.description.abstract | The neuroprotective potential of flavonoids within the brain comprises anti-apoptosis of neuronal cells, anti-neuroinflammation and enhancement of cognitive function. We reported that Rhus vernciflua inhibits glutamate-induced neurotoxicity in primary cultured rat cortical cells. Here we narrowed it down to get neuroprotective fractions from the plant yielding flavonoid-rich ethyl acetate fraction (PREF). Among its active flavonoids, fisetin exhibited not only inhibitory effect against lipopolysaccharide (LPS)-induced neuroinflammation by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 but also memory enhancing effects via reactivation of cAMP responsive element binding protein (CREB)-brain derived neurotrophic factor (BDNF) pathway in memory-impaired mice by scopolamine. Butein also showed a similar activity to fisetin even though to a lesser extent. The neuroprotection by PREF and selected flavonoids may involve maintenance of antioxidant defense mechanism including glutathione peroxidase (GSH-Px), glutathione reductase (GR) and superoxide dismutase (SOD). Conclusively, we demonstrate the R. vernciflua bark extract and its active flavonoids with potent neuroprotective and anti-inflammatory effects might be good therapeutic candidates as cognitive-enhancers. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | CELLS | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | BRAIN | - |
dc.subject | EXPRESSION | - |
dc.subject | PATHWAY | - |
dc.subject | CANCER | - |
dc.title | Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.identifier.doi | 10.1016/j.fct.2013.05.007 | - |
dc.identifier.scopusid | 2-s2.0-84879318335 | - |
dc.identifier.wosid | 000322099100047 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.58, pp.355 - 361 | - |
dc.relation.isPartOf | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 58 | - |
dc.citation.startPage | 355 | - |
dc.citation.endPage | 361 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | Rhus verniciflua bark | - |
dc.subject.keywordAuthor | Flavonoids | - |
dc.subject.keywordAuthor | Cognitive-enhancing activity | - |
dc.subject.keywordAuthor | Anti-neuroinflammation | - |
dc.subject.keywordAuthor | CREB-BDNF signaling | - |
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