Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities
- Authors
- Cho, Namki; Lee, Ki Yong; Huh, Jungmoo; Choi, Ji Hoon; Yang, Heejung; Jeong, Eun Ju; Kim, Hong Pyo; Sung, Sang Hyun
- Issue Date
- 8월-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Rhus verniciflua bark; Flavonoids; Cognitive-enhancing activity; Anti-neuroinflammation; CREB-BDNF signaling
- Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.58, pp.355 - 361
- Indexed
- SCIE
SCOPUS
- Journal Title
- FOOD AND CHEMICAL TOXICOLOGY
- Volume
- 58
- Start Page
- 355
- End Page
- 361
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102581
- DOI
- 10.1016/j.fct.2013.05.007
- ISSN
- 0278-6915
- Abstract
- The neuroprotective potential of flavonoids within the brain comprises anti-apoptosis of neuronal cells, anti-neuroinflammation and enhancement of cognitive function. We reported that Rhus vernciflua inhibits glutamate-induced neurotoxicity in primary cultured rat cortical cells. Here we narrowed it down to get neuroprotective fractions from the plant yielding flavonoid-rich ethyl acetate fraction (PREF). Among its active flavonoids, fisetin exhibited not only inhibitory effect against lipopolysaccharide (LPS)-induced neuroinflammation by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 but also memory enhancing effects via reactivation of cAMP responsive element binding protein (CREB)-brain derived neurotrophic factor (BDNF) pathway in memory-impaired mice by scopolamine. Butein also showed a similar activity to fisetin even though to a lesser extent. The neuroprotection by PREF and selected flavonoids may involve maintenance of antioxidant defense mechanism including glutathione peroxidase (GSH-Px), glutathione reductase (GR) and superoxide dismutase (SOD). Conclusively, we demonstrate the R. vernciflua bark extract and its active flavonoids with potent neuroprotective and anti-inflammatory effects might be good therapeutic candidates as cognitive-enhancers. (C) 2013 Elsevier Ltd. All rights reserved.
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