Production, mechanical properties and in vitro biocompatibility of highly aligned porous poly(epsilon-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds
DC Field | Value | Language |
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dc.contributor.author | Choi, Won-Young | - |
dc.contributor.author | Kim, Hyoun-Ee | - |
dc.contributor.author | Koh, Young-Hag | - |
dc.date.accessioned | 2021-09-05T23:20:43Z | - |
dc.date.available | 2021-09-05T23:20:43Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1380-2224 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102604 | - |
dc.description.abstract | We produced highly aligned porous poly(epsilon-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds by unidirectionally freezing PCL/HA solutions with various HA contents (0, 5, 10 and 20 wt% in relation to the PCL polymer) and evaluated their mechanical properties and in vitro biocompatibility to examine their potential applications in bone tissue engineering. All the prepared scaffolds had a highly aligned porous structure, in which the HA particles were uniformly dispersed in the PCL walls. The elastic modulus of the PCL/HA scaffolds significantly increased from 0.12 +/- A 0.02 to 2.65 +/- A 0.05 MPa with increasing initial HA content from 0 to 20 wt%, whereas the pore size decreased from 9.2 +/- A 0.7 to 4.2 +/- A 0.8 mu m. In addition, the PCL/HA scaffolds showed considerably enhanced in vitro cellular responses that were assessed in terms of cell attachment, proliferation and osteoblastic differentiation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | COMPOSITE SCAFFOLDS | - |
dc.subject | PHASE-SEPARATION | - |
dc.subject | BONE | - |
dc.subject | FABRICATION | - |
dc.subject | ARCHITECTURE | - |
dc.title | Production, mechanical properties and in vitro biocompatibility of highly aligned porous poly(epsilon-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Young-Hag | - |
dc.identifier.doi | 10.1007/s10934-012-9644-4 | - |
dc.identifier.scopusid | 2-s2.0-84879882795 | - |
dc.identifier.wosid | 000321127100014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF POROUS MATERIALS, v.20, no.4, pp.701 - 708 | - |
dc.relation.isPartOf | JOURNAL OF POROUS MATERIALS | - |
dc.citation.title | JOURNAL OF POROUS MATERIALS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 701 | - |
dc.citation.endPage | 708 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | COMPOSITE SCAFFOLDS | - |
dc.subject.keywordPlus | PHASE-SEPARATION | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | ARCHITECTURE | - |
dc.subject.keywordAuthor | Poly(epsilon-caprolactone) (PCL) | - |
dc.subject.keywordAuthor | Hydroxyapatite | - |
dc.subject.keywordAuthor | Scaffold | - |
dc.subject.keywordAuthor | Porous | - |
dc.subject.keywordAuthor | Biocompatibility | - |
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