Improvement of Osteoblast Functions by Sustained Release of Bone Morphogenetic Protein-2 (BMP-2) from Heparin-coated Chitosan Scaffold
DC Field | Value | Language |
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dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Lee, Su-Young | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.date.accessioned | 2021-09-05T23:26:56Z | - |
dc.date.available | 2021-09-05T23:26:56Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102641 | - |
dc.description.abstract | The aim of this study was to investigate the improvement in osteoblast functions by using bone morphogenetic protein-2 (BMP-2) immobilized heparin-coated chitosan scaffolds and comparing it with that using chitosan scaffold or BMP-2/chitosan scaffold in vitro. BMP-2 was released from the heparin-coated chitosan scaffold in a sustained manner compared to that released from the chitosan scaffold. The osteoblast functions of MG-63 cells grown on the chitosan scaffold, the BMP-2/chitosan scaffold, the BMP-2/Hep/chitosan scaffold were investigated by assessing cell proliferation, alkaline phosphatase (ALP) activity, calcium deposition, and gene expression. The results of the in vitro studies demonstrated that MG-63 cells grown on the BMP-2/Hep/chitosan scaffold showed a significant increment in ALP activity, and calcium deposition as compared to those grown on the chitosan scaffold by sustained release of BMP-2 due to the influence of heparin. Therefore, BMP-2 immobilized heparin-coated chitosan scaffolds are promising materials for improving osteoblast functions through sustained release of BMP-2. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | - |
dc.subject | STEM-CELLS | - |
dc.subject | DELIVERY | - |
dc.subject | ENHANCEMENT | - |
dc.subject | TITANIUM | - |
dc.subject | FUNCTIONALIZATION | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | IMMOBILIZATION | - |
dc.subject | MICROSPHERES | - |
dc.subject | INDUCTION | - |
dc.subject | HYDROGEL | - |
dc.title | Improvement of Osteoblast Functions by Sustained Release of Bone Morphogenetic Protein-2 (BMP-2) from Heparin-coated Chitosan Scaffold | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.identifier.doi | 10.1007/s13770-013-0389-1 | - |
dc.identifier.scopusid | 2-s2.0-84896723879 | - |
dc.identifier.wosid | 000323082700005 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.10, no.4, pp.183 - 191 | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.title | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 183 | - |
dc.citation.endPage | 191 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001791137 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | TITANIUM | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | HYDROGEL | - |
dc.subject.keywordAuthor | bone morphogenetic protein-2 (BMP-2) | - |
dc.subject.keywordAuthor | heparin | - |
dc.subject.keywordAuthor | osteoblast function | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordAuthor | chitosan scaffold | - |
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