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Improvement of Osteoblast Functions by Sustained Release of Bone Morphogenetic Protein-2 (BMP-2) from Heparin-coated Chitosan Scaffold

Authors
Yun, Young-PilLee, Su-YoungKim, Hak-JunSong, Jae-JunKim, Sung Eun
Issue Date
8월-2013
Publisher
KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
Keywords
bone morphogenetic protein-2 (BMP-2); heparin; osteoblast function; sustained release; chitosan scaffold
Citation
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.10, no.4, pp.183 - 191
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume
10
Number
4
Start Page
183
End Page
191
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/102641
DOI
10.1007/s13770-013-0389-1
ISSN
1738-2696
Abstract
The aim of this study was to investigate the improvement in osteoblast functions by using bone morphogenetic protein-2 (BMP-2) immobilized heparin-coated chitosan scaffolds and comparing it with that using chitosan scaffold or BMP-2/chitosan scaffold in vitro. BMP-2 was released from the heparin-coated chitosan scaffold in a sustained manner compared to that released from the chitosan scaffold. The osteoblast functions of MG-63 cells grown on the chitosan scaffold, the BMP-2/chitosan scaffold, the BMP-2/Hep/chitosan scaffold were investigated by assessing cell proliferation, alkaline phosphatase (ALP) activity, calcium deposition, and gene expression. The results of the in vitro studies demonstrated that MG-63 cells grown on the BMP-2/Hep/chitosan scaffold showed a significant increment in ALP activity, and calcium deposition as compared to those grown on the chitosan scaffold by sustained release of BMP-2 due to the influence of heparin. Therefore, BMP-2 immobilized heparin-coated chitosan scaffolds are promising materials for improving osteoblast functions through sustained release of BMP-2.
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