The effects of pre-emptive low-dose X-ray irradiation on MIA induced inflammatory pain in rats
- Authors
- Hahm, Suk-Chan; Lee, Go-Eun; Kim, Eun-Hye; Kim, Junesun; Lee, Taewoong; Lee, Wonho
- Issue Date
- 7월-2013
- Publisher
- KOREAN PHYSICAL SOC
- Keywords
- Inflammatory pain; Osteoarthritis; X-radiation; iNOS; Spontaneous pain; Allodynia; Thermal hyperadesia
- Citation
- JOURNAL OF THE KOREAN PHYSICAL SOCIETY, v.63, no.2, pp.269 - 275
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF THE KOREAN PHYSICAL SOCIETY
- Volume
- 63
- Number
- 2
- Start Page
- 269
- End Page
- 275
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102792
- DOI
- 10.3938/jkps.63.269
- ISSN
- 0374-4884
- Abstract
- This study was performed to determine the effect of pre-emptive low-dose irradiation on the development of inflammatory pain and to characterize the potential mechanisms underlying this effect in osteoarthritis (OA) animal model. Whole-body X-irradiations with 0.1, 0.5, 1 Gy or sham irradiations were performed for 3 days before the induction of ostearthritis with monosodium iodoacetate (MIA) (40 A mu l, in saline) into the right knee joint in male Sprague Dawley rats. Behavioral tests for arthritic pain including evoked and non-evoked pain were conducted before and after MIA injection and inducible nitric-oxide synthase (iNOS) expression level was measured by western blot. Low-dose radiation significantly prevented the development of mechanical allodynia and thermal hyperalgesia and reduction in weight bearing that is regarded as a behavioral signs of non-evoked pain following MIA injection. Low-dose radiation significantly inhibited the increase in iNOS expression after MIA injection in spinal L3-5 segments in rat. These data suggest that low-dose X-irradiation is able to prevent the development of arthritic pain through modulation of iNOS expression in the spinal cord dorsal horn. Thus, low-dose radiotherapy could be substituted in part for treatment with drugs for patients with chronic inflammatory disease in clinical setting.
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