Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D-3 in human monocytes/macrophages
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Lee, Bitnara | - |
dc.contributor.author | Kwon, Eunji | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Sohn, Jeongwon | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.date.accessioned | 2021-09-06T00:11:38Z | - |
dc.date.available | 2021-09-06T00:11:38Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102825 | - |
dc.description.abstract | Triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified cell surface receptor that is expressed mainly on monocytes and neutrophils, and acts as an amplifier of immune responses. In this study, 1,25(OH)(2)D-3 strongly upregulated the expression of TEEM-1 in human monocytes and macrophages. 1,25(OH)(2)D-3 stimulated TREM-1 mRNA expression by augmenting transcription, and not by inhibiting mRNA degradation. The upregulated expression of TREM-1 by 1,25(OH)(2)D-3 was dependent on the NF-kappa B signaling pathway and required new protein synthesis in differentiated U937 macrophages. Our results show that 1,25(OH)(2)D-3 can affect the innate and inflammatory responses by upregulating TEEM-1 expression, and suggest that 1,25(OH)(2)D-3 may function as an enhancer of the innate immune response by upregulating TREM-1 expression, in addition to inducing the antimicrobial peptide cathelicidin. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | MYELOID CELLS-1 | - |
dc.subject | VITAMIN-D | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | CUTTING EDGE | - |
dc.subject | RECEPTOR | - |
dc.subject | MACROPHAGES | - |
dc.subject | ENDOTOXEMIA | - |
dc.subject | INDUCTION | - |
dc.subject | MONOCYTES | - |
dc.title | Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D-3 in human monocytes/macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Sohn, Jeongwon | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.identifier.doi | 10.1016/j.imlet.2013.08.012 | - |
dc.identifier.scopusid | 2-s2.0-84884336462 | - |
dc.identifier.wosid | 000326559400013 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY LETTERS, v.154, no.1-2, pp.80 - 85 | - |
dc.relation.isPartOf | IMMUNOLOGY LETTERS | - |
dc.citation.title | IMMUNOLOGY LETTERS | - |
dc.citation.volume | 154 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 85 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | MYELOID CELLS-1 | - |
dc.subject.keywordPlus | VITAMIN-D | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | ENDOTOXEMIA | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MONOCYTES | - |
dc.subject.keywordAuthor | TREM-1 | - |
dc.subject.keywordAuthor | 1,25-Dihydroxyviamin D-3 | - |
dc.subject.keywordAuthor | Monocytes | - |
dc.subject.keywordAuthor | Macrophages | - |
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