Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D-3 in human monocytes/macrophages
- Authors
- Kim, Tae-Hwan; Lee, Bitnara; Kwon, Eunji; Choi, Sung Jae; Lee, Young Ho; Song, Gwan Gyu; Sohn, Jeongwon; Ji, Jong Dae
- Issue Date
- 7월-2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- TREM-1; 1,25-Dihydroxyviamin D-3; Monocytes; Macrophages
- Citation
- IMMUNOLOGY LETTERS, v.154, no.1-2, pp.80 - 85
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNOLOGY LETTERS
- Volume
- 154
- Number
- 1-2
- Start Page
- 80
- End Page
- 85
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102825
- DOI
- 10.1016/j.imlet.2013.08.012
- ISSN
- 0165-2478
- Abstract
- Triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified cell surface receptor that is expressed mainly on monocytes and neutrophils, and acts as an amplifier of immune responses. In this study, 1,25(OH)(2)D-3 strongly upregulated the expression of TEEM-1 in human monocytes and macrophages. 1,25(OH)(2)D-3 stimulated TREM-1 mRNA expression by augmenting transcription, and not by inhibiting mRNA degradation. The upregulated expression of TREM-1 by 1,25(OH)(2)D-3 was dependent on the NF-kappa B signaling pathway and required new protein synthesis in differentiated U937 macrophages. Our results show that 1,25(OH)(2)D-3 can affect the innate and inflammatory responses by upregulating TEEM-1 expression, and suggest that 1,25(OH)(2)D-3 may function as an enhancer of the innate immune response by upregulating TREM-1 expression, in addition to inducing the antimicrobial peptide cathelicidin. (C) 2013 Elsevier B.V. All rights reserved.
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