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Repression of Antibiotic Downregulator WblA by AdpA in Streptomyces coelicolor
- Authors
- Lee, Han-Na; Kim, Jin-Su; Kim, Pil; Lee, Heung-Shick; Kim, Eung-Soo
- Issue Date
- Jul-2013
- Publisher
- AMER SOC MICROBIOLOGY
- Citation
- APPLIED AND ENVIRONMENTAL MICROBIOLOGY, v.79, no.13, pp.4159 - 4163
- Indexed
- SCIE
SCOPUS
- Journal Title
- APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Volume
- 79
- Number
- 13
- Start Page
- 4159
- End Page
- 4163
- ISSN
- 0099-2240
- Abstract
- The upstream region of antibiotic downregulatory wblA in Streptomyces coelicolor was found to contain AdpA binding motifs. A key morphological regulator, AdpA was shown to specifically bind these motifs by electrophoretic mobility shift assay. An adpA disruption mutant exhibited increased wblA transcription, suggesting that AdpA negatively regulates wblA transcription in S. coelicolor.
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Related Researcher
- Lee, Heung Shick
- Department of Biotechnology and Bioinformatics