Peyer's patch-mediated intestinal immune system modulating activity of pectic-type polysaccharide from peel of Citrus unshiu
DC Field | Value | Language |
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dc.contributor.author | Suh, Hyung-Joo | - |
dc.contributor.author | Yang, Hyun-Seuk | - |
dc.contributor.author | Ra, Kyung-Soo | - |
dc.contributor.author | Noh, Dong-Ouk | - |
dc.contributor.author | Kwon, Ki-Han | - |
dc.contributor.author | Hwang, Jong-Hyun | - |
dc.contributor.author | Yu, Kwang-Won | - |
dc.date.accessioned | 2021-09-06T00:44:00Z | - |
dc.date.available | 2021-09-06T00:44:00Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2013-06-01 | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/102992 | - |
dc.description.abstract | An intestinal immune system modulating polysaccharide (CUI-3IIb-3-2, 18 kDa) was purified from Citrus unshiu peel. CUI-3IIb-3-2 mainly comprised GalA, GlcA, Ara, Gal and Rha, and it consisted of 4-linked GalA, terminal Araf, 4- or 5-linked/3,4- or 3,5-branched Ara, terminal Gal, and 2-linked/2,4-branched Rha. After CUI-3IIb-3-2 digestion by endo-alpha-D-(1 -> 4)-polygalacturonase, its hydrolysate was fractionated into PG-1 and PG-2. Methylation analyses of PG-1 and PG-2 using base-catalysed beta-elimination suggested that CUI-3IIb-3-2 be assumed as pectic-type polysaccharide. Since the activities of PG-1 and PG-2 were potently decreased, the whole polysaccharide structure of CUI-3IIb-3-2 would be essential to maintain the activity. Meanwhile, when CUI-3IIb was orally administered in mice, bone marrow cell proliferation and GM-CSF/IL-6 production from Peyer's patch cell were significantly higher (1.76- and 2.03/2.51-fold, respectively) than a saline. Therefore, a pectic-type polysaccharide from citrus peel could stimulate Peyer's patches and produce hematopoietic growth factors resulted in bone marrow cell proliferation. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | PLANT-CELL WALLS | - |
dc.subject | RHAMNOGALACTURONAN-I | - |
dc.subject | ROOTS | - |
dc.subject | VITRO | - |
dc.subject | CSF | - |
dc.title | Peyer's patch-mediated intestinal immune system modulating activity of pectic-type polysaccharide from peel of Citrus unshiu | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung-Joo | - |
dc.identifier.doi | 10.1016/j.foodchem.2012.11.091 | - |
dc.identifier.scopusid | 2-s2.0-84873739595 | - |
dc.identifier.wosid | 000316039500050 | - |
dc.identifier.bibliographicCitation | FOOD CHEMISTRY, v.138, no.2-3, pp.1079 - 1086 | - |
dc.relation.isPartOf | FOOD CHEMISTRY | - |
dc.citation.title | FOOD CHEMISTRY | - |
dc.citation.volume | 138 | - |
dc.citation.number | 2-3 | - |
dc.citation.startPage | 1079 | - |
dc.citation.endPage | 1086 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | PLANT-CELL WALLS | - |
dc.subject.keywordPlus | RHAMNOGALACTURONAN-I | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | CSF | - |
dc.subject.keywordAuthor | Citrus unshiu peel, Pectic-type polysaccharide | - |
dc.subject.keywordAuthor | Base-catalysed beta-elimination | - |
dc.subject.keywordAuthor | Peyer&apos | - |
dc.subject.keywordAuthor | s patch | - |
dc.subject.keywordAuthor | Intestinal immune system modulating activity | - |
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