Free Prostate-Specific Antigen Provides More Precise Data on Benign Prostate Volume Than Total Prostate-Specific Antigen in Korean Population
- Authors
- Choi, Hoon; Park, Jae Young; Shim, Ji Sung; Kim, Jae Heon; Bae, Jae Hyun
- Issue Date
- 6월-2013
- Publisher
- KOREAN CONTINENCE SOC
- Keywords
- Prostate-specific antigen; Prostatic hyperplasia; Organ volume
- Citation
- INTERNATIONAL NEUROUROLOGY JOURNAL, v.17, no.2, pp.73 - 77
- Indexed
- SCOPUS
KCI
- Journal Title
- INTERNATIONAL NEUROUROLOGY JOURNAL
- Volume
- 17
- Number
- 2
- Start Page
- 73
- End Page
- 77
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103005
- DOI
- 10.5213/inj.2013.17.2.73
- ISSN
- 2093-4777
- Abstract
- Purpose: To investigate the efficacy of total prostate-specific antigen (tPSA) and free prostate-specific antigen (fPSA) for the estimation of prostate volume (PV) in pathologically-proven benign prostatic hyperplasia (BPH) patients. Methods: From January 2010 to March 2013, 165 Korean men with a PSA less than 10 ng/mL who were diagnosed without prostate cancer by prostate biopsy were enrolled. Patients were classified into three age groups: <= 60, 61-70, and >70 years old. The results were organized to estimate and compare the ability of serum tPSA and fPSA to assess the PV. Results: Enrolled patients had a median age of 63.5 years (44 to 80), a median tPSA of 5.72 ng/mL, a median fPSA of 0.98 ng/mL and a median PV of 53.68 mL, respectively. Among the associations between tPSA, fPSA, age, and PV, the highest correlation was verified between fPSA and PV (r = 0.377, P < 0.0001); the correlation coefficient between tPSA and PV was much lower (r = 0.262, P < 0.001). All stratified age cohorts showed the same findings. The ROC curves (for PV greater than 30, 40, and 50 mL) showed that fPSA (area under the curve [AUC] = 0.781, 0.718, and 0.700) outperformed tPSA (AUC = 0.657, 0.583, and 0.67) in its ability to predict clinically significant PV enlargement. Conclusion: Both tPSA and fPSA significantly correlated with PV in Korean men, while the correlation efficiency between fPSA and PV was more powerful. fPSA may be a useful tool in making therapeutic decisions and follow-up management in BPH patients.
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