The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant
- Authors
- Kim, Jong-Eun; Kang, Seong-Su; Choi, Kyung-Hee; Shim, June-Sung; Jeong, Chang-Mo; Shin, Sang-Wan; Huh, Jung-Bo
- Issue Date
- 6월-2013
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v.115, no.6, pp.E24 - E31
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
- Volume
- 115
- Number
- 6
- Start Page
- E24
- End Page
- E31
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103017
- DOI
- 10.1016/j.oooo.2011.10.040
- ISSN
- 2212-4403
- Abstract
- Objectives. The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant. Study Design. Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks. Results. The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P < .05). Conclusions. Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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