Fluorogenic pH-Sensitive Polydiacetylene (PDA) Liposomes as a Drug Carrier
DC Field | Value | Language |
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dc.contributor.author | Won, Sang Ho | - |
dc.contributor.author | Lee, Jong Uk | - |
dc.contributor.author | Sim, Sang Jun | - |
dc.date.accessioned | 2021-09-06T00:54:52Z | - |
dc.date.available | 2021-09-06T00:54:52Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103031 | - |
dc.description.abstract | A crucial issue for current liposomal carriers in clinical applications is the sustained-release property of the encapsulated drugs. We have developed novel fluorogenic pH-sensitive polymerized liposomes composed of polydiacetylene (PDA) lipids and other types of lipids. Unilamellar liposomes containing 10,12-pentacosadiynoic acid (PCDA), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and N-palmitoyl homocysteine (PHC) were loaded with ampicillin. These liposomes fused to each other rapidly when the medium pH was lowered from 7 to 4. The polymerized liposomes were characterized in terms of particle size distribution. The liposome size increased approximately 20-fold from 110.0 +/- 19.3 nm to 2046.7 +/- 487.4 nm as the pH was lowered. Cross-linking of the diacetylene lipids prevents drug leakage and the encapsulated drug can be instantaneously released at acidic pH condition. The ampicillin was nearly completely released (74.4 +/- 3.9%) from liposomes within 4 h under acidic pH conditions and the released amounts of ampicillin were analyzed by HPLC. Finally, the therapeutic effect was observed by the appearance of plaques on a lawn of E. coli, and fluorescent images of the PDA liposomes were taken from the plaques for drug release monitoring. As a result, this research demonstrates that such novel pH-sensitive polymerized liposomes have great prospects as a drug carrier. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.subject | AQUEOUS-SOLUTION | - |
dc.subject | MEMBRANE-FUSION | - |
dc.subject | DELIVERY | - |
dc.subject | NANOCARRIERS | - |
dc.subject | AMPICILLIN | - |
dc.subject | CANCER | - |
dc.subject | ACID | - |
dc.subject | ANTIBIOTICS | - |
dc.subject | STABILITY | - |
dc.subject | MECHANISM | - |
dc.title | Fluorogenic pH-Sensitive Polydiacetylene (PDA) Liposomes as a Drug Carrier | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sim, Sang Jun | - |
dc.identifier.doi | 10.1166/jnn.2013.7205 | - |
dc.identifier.scopusid | 2-s2.0-84878744302 | - |
dc.identifier.wosid | 000320205400005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.13, no.6, pp.3792 - 3800 | - |
dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.volume | 13 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 3792 | - |
dc.citation.endPage | 3800 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTION | - |
dc.subject.keywordPlus | MEMBRANE-FUSION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | AMPICILLIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | Polydiacetylene | - |
dc.subject.keywordAuthor | Liposome | - |
dc.subject.keywordAuthor | Fluorescence | - |
dc.subject.keywordAuthor | Drug Carrier | - |
dc.subject.keywordAuthor | pH-Sensitive | - |
dc.subject.keywordAuthor | Ampicillin | - |
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