There is no evidence for an association between the serotonin receptor 3A gene C178T polymorphism and tardive dyskinesia in Korean schizophrenia patients
- Authors
- Kang, Seung-Gul; Lee, Heon-Jeong; Yoon, Ho-Kyoung; Cho, Sung Nam; Park, Young-Min; Kim, Leen
- Issue Date
- 6월-2013
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Association; Polymorphism; Schizophrenia; Serotonin receptor 3A gene; Tardive dyskinesia
- Citation
- NORDIC JOURNAL OF PSYCHIATRY, v.67, no.3, pp.214 - 218
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- NORDIC JOURNAL OF PSYCHIATRY
- Volume
- 67
- Number
- 3
- Start Page
- 214
- End Page
- 218
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103064
- DOI
- 10.3109/08039488.2012.732114
- ISSN
- 0803-9488
- Abstract
- Background: Tardive dyskinesia (TD) is a potential adverse effect of long-term treatment with antipsychotics. Previous studies have suggested a link between brain serotonergic systems and TD vulnerability. A recent report described that a serotonin 3 receptor (5-HTR3) agonist induced rhythmic movements in mice with complete paraplegia. Furthermore, it has been reported that the 5-HTR3 antagonist ondansetron is efficacious in the treatment of Gilles de la Tourette syndrome (GTS). Aim: The aim of the present study was to determine whether the 5-HTR3A gene C178T polymorphism is associated with antipsychotic-induced TD in Korean schizophrenia patients. Methods: We investigated 280 Korean schizophrenia patients. Subjects with TD (n = 105) and without TD (n = 175) were matched for antipsychotic drug exposure and other relevant variables. Results: The distributions of genotypic (chi-squared = 3.55, p = 0.169) and allelic (chi-squared = 0.40, p = 0.528) frequencies did not differ between patients with and without TD. The total score on the Abnormal Involuntary Movement Scale also did not differ between the two genotype groups (F = 0.94, p = 0.391). Conclusions: The findings of the present study do not support the involvement of the 5-HTR3A gene C178T polymorphism in TD in Korean schizophrenia subjects.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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