The effect of oxidized low-density lipoprotein (ox-LDL) on radiation-induced endothelial-to-mesenchymal transition
DC Field | Value | Language |
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dc.contributor.author | Kim, Miseon | - |
dc.contributor.author | Choi, Seo-Hyun | - |
dc.contributor.author | Jin, Yeung Bae | - |
dc.contributor.author | Lee, Hae-June | - |
dc.contributor.author | Ji, Young Hoon | - |
dc.contributor.author | Kim, Joon | - |
dc.contributor.author | Lee, Yun-Sil | - |
dc.contributor.author | Lee, Yoon-Jin | - |
dc.date.accessioned | 2021-09-06T02:03:43Z | - |
dc.date.available | 2021-09-06T02:03:43Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 0955-3002 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103370 | - |
dc.description.abstract | Purpose : Radiation-induced cardiovascular disease is a potentially severe side-effect of thoracic radiotherapy treatment. Clinically, this delayed side-effect presents as a form of accelerated atherosclerosis several years after irradiation. As general endothelial dysfunction is known to be an initiating event in radiation-induced vascular damage, we examined the effects of radiation on endothelial cells in radiation-induced atherosclerosis. Materials and methods : The effects of radiation on human aortic endothelial cells (HAoEC) were assessed by immunoblotting and immunofluorescence assays. Radiation-induced phenotypic changes of endothelial cells (ECs) were examined using atherosclerotic tissues of irradiated apoprotein E null (ApoE(-/-)) mice. Results : Radiation induced the HAoEC to undergo phenotypic conversion to form fibroblast-like cells, called the endothelial-to-mesenchymal transition (EndMT), which leads to the upregulation of mesenchymal cell markers such as alpha-smooth muscle actin (alpha-SMA), fibroblast specific protein-1 (FSP-1), and vimentin, and downregulation of endothelial cell-specific markers such as CD31 and vascular endothelial (VE)-cadherin. Furthermore, compared with low-density lipoprotein (LDL), oxidized low-density lipoprotein (ox-LDL) significantly augmented radiation-induced EndMT in HAoEC. These fibrotic phenotypes of ECs were found in atherosclerotic tissues of irradiated ApoE(-/-) mice with increased levels of ox-LDL. Conclusions : Taken together, these observations suggest that ox-LDL accelerates radiation-induced EndMT and subsequently contributes to radiation-induced atherosclerosis, providing a novel target for the prevention of radiation-induced atherosclerosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.subject | INFLAMMATORY PLAQUE PHENOTYPE | - |
dc.subject | INDUCED HEART-DISEASE | - |
dc.subject | BREAST-CANCER | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | NECK IRRADIATION | - |
dc.subject | CARDIAC FIBROSIS | - |
dc.subject | HODGKINS-DISEASE | - |
dc.subject | APOE(-/-) MICE | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | RADIOTHERAPY | - |
dc.title | The effect of oxidized low-density lipoprotein (ox-LDL) on radiation-induced endothelial-to-mesenchymal transition | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.3109/09553002.2013.763193 | - |
dc.identifier.scopusid | 2-s2.0-84877307533 | - |
dc.identifier.wosid | 000318357000006 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, v.89, no.5, pp.356 - 363 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | - |
dc.citation.volume | 89 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 356 | - |
dc.citation.endPage | 363 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Nuclear Science & Technology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Nuclear Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | INFLAMMATORY PLAQUE PHENOTYPE | - |
dc.subject.keywordPlus | INDUCED HEART-DISEASE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | NECK IRRADIATION | - |
dc.subject.keywordPlus | CARDIAC FIBROSIS | - |
dc.subject.keywordPlus | HODGKINS-DISEASE | - |
dc.subject.keywordPlus | APOE(-/-) MICE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | radiation | - |
dc.subject.keywordAuthor | endothelial-to-mesenchymal transition (EndMT) | - |
dc.subject.keywordAuthor | oxidized low-density lipoprotein (ox-LDL) | - |
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