A Comparative Pilot Study of Symptom Improvement Before and After Phototherapy in Korean Patients with Perennial Allergic Rhinitis
- Authors
- Lee, Heung-Man; Park, Man Sik; Park, Il Ho; Lee, Seung Hoon; Lee, Seong Keon; Kim, Kyu-Sung; Choi, Hyuk
- Issue Date
- 5월-2013
- Publisher
- WILEY
- Citation
- PHOTOCHEMISTRY AND PHOTOBIOLOGY, v.89, no.3, pp.751 - 757
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHOTOCHEMISTRY AND PHOTOBIOLOGY
- Volume
- 89
- Number
- 3
- Start Page
- 751
- End Page
- 757
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103452
- DOI
- 10.1111/php.12032
- ISSN
- 0031-8655
- Abstract
- Although allergic rhinitis is not life threatening, it significantly influences the quality of a patient's life. This study is intended to evaluate the safety and efficacy of phototherapy with low-level energy of a 650nm laser irradiation system in perennial allergic rhinitis patients. This clinical trial was an open-label, single-center study with 42 perennial allergic rhinitis subjects. Following laser irradiation in the nasal cavity with a laser irradiation system, the efficacy at weeks 1 through 4 was determined. The symptoms were scored with four parameters (nasal obstruction, rhinorrhea, sneezing and itching) before and after illumination of the laser, and the total score was recorded. A survey of Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was conducted by patients before and after treatment. Following treatment, significant improvement in the clinical symptoms of nasal obstruction (P<0.001), rhinorrhea (P=0.005), sneezing (P=0.001) and itching (P=0.003) was reported by 68% of perennial allergic rhinitis patients. The overall RQLQ scores significantly improved by 45% from the baseline with the treatment after 4weeks. These results indicate that phototherapy is an effective modality for treating perennial allergic rhinitis and is another option in the steroid-free management of immune-mediated mucosal diseases.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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