Non-Invasive Brain-to-Brain Interface (BBI): Establishing Functional Links between Two Brains
DC Field | Value | Language |
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dc.contributor.author | Yoo, Seung-Schik | - |
dc.contributor.author | Kim, Hyungmin | - |
dc.contributor.author | Filandrianos, Emmanuel | - |
dc.contributor.author | Taghados, Seyed Javid | - |
dc.contributor.author | Park, Shinsuk | - |
dc.date.accessioned | 2021-09-06T02:41:37Z | - |
dc.date.available | 2021-09-06T02:41:37Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-04-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103520 | - |
dc.description.abstract | Transcranial focused ultrasound (FUS) is capable of modulating the neural activity of specific brain regions, with a potential role as a non-invasive computer-to-brain interface (CBI). In conjunction with the use of brain-to-computer interface (BCI) techniques that translate brain function to generate computer commands, we investigated the feasibility of using the FUS-based CBI to non-invasively establish a functional link between the brains of different species (i.e. human and Sprague-Dawley rat), thus creating a brain-to-brain interface (BBI). The implementation was aimed to non-invasively translate the human volunteer's intention to stimulate a rat's brain motor area that is responsible for the tail movement. The volunteer initiated the intention by looking at a strobe light flicker on a computer display, and the degree of synchronization in the electroencephalographic steady-state-visual-evoked-potentials (SSVEP) with respect to the strobe frequency was analyzed using a computer. Increased signal amplitude in the SSVEP, indicating the volunteer's intention, triggered the delivery of a burst-mode FUS (350 kHz ultrasound frequency, tone burst duration of 0.5 ms, pulse repetition frequency of 1 kHz, given for 300 msec duration) to excite the motor area of an anesthetized rat transcranially. The successful excitation subsequently elicited the tail movement, which was detected by a motion sensor. The interface was achieved at 94.0 +/- 3.0% accuracy, with a time delay of 1.59 +/- 1.07 sec from the thought-initiation to the creation of the tail movement. Our results demonstrate the feasibility of a computer-mediated BBI that links central neural functions between two biological entities, which may confer unexplored opportunities in the study of neuroscience with potential implications for therapeutic applications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | FOCUSED ULTRASOUND | - |
dc.subject | COMPUTER INTERFACES | - |
dc.subject | REAL-TIME | - |
dc.subject | NAVIGATION | - |
dc.subject | INTENSITY | - |
dc.subject | DEVICE | - |
dc.subject | CORTEX | - |
dc.subject | FMRI | - |
dc.title | Non-Invasive Brain-to-Brain Interface (BBI): Establishing Functional Links between Two Brains | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Shinsuk | - |
dc.identifier.doi | 10.1371/journal.pone.0060410 | - |
dc.identifier.scopusid | 2-s2.0-84875716104 | - |
dc.identifier.wosid | 000318840100066 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.8, no.4 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | FOCUSED ULTRASOUND | - |
dc.subject.keywordPlus | COMPUTER INTERFACES | - |
dc.subject.keywordPlus | REAL-TIME | - |
dc.subject.keywordPlus | NAVIGATION | - |
dc.subject.keywordPlus | INTENSITY | - |
dc.subject.keywordPlus | DEVICE | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | FMRI | - |
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