Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(epsilon-caprolactone) composites for bone tissue engineering
- Authors
- Lei, Bo; Shin, Kwan-Ha; Noh, Da-Young; Jo, In-Hwan; Koh, Young-Hag; Kim, Hyoun-Ee; Kim, Sung Eun
- Issue Date
- 1-4월-2013
- Publisher
- ELSEVIER
- Keywords
- Bioactive glass; Biodegradation; Polymer; Composite; Hard tissue; Mechanical properties
- Citation
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.33, no.3, pp.1102 - 1108
- Indexed
- SCIE
SCOPUS
- Journal Title
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
- Volume
- 33
- Number
- 3
- Start Page
- 1102
- End Page
- 1108
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103526
- DOI
- 10.1016/j.msec.2012.11.039
- ISSN
- 0928-4931
- Abstract
- This study investigated the effect of the addition of sal-gel derived nanoscale bioactive glass (NBG) particles on the mechanical properties and biological performances of PCL polymer, in order to evaluate the potential applications of PCL/NBG composites for bone tissue regeneration. Regardless of the NBG contents (10, 20, and 30 wt.%), the NBG particles, which were synthesized through the sol-gel process using polyethylene glycol (PEG) polymer as a template, could be uniformly dispersed in the PCL matrix, while generating pores in the PCL/NBG composites. The elastic modulus of the PCL/NBG composites increased remarkably from 89 +/- 11 MPa to 383 +/- 50 MPa with increasing NBG content from 0 to 30 wt.%, while still showing good ultimate tensile strength in the range of 15-19 MPa. The hydrophilicity, water absorption and degradation behavior of the PCL/NBG composites were also enhanced by the addition of the NBG particles. Furthermore, the PCL/NBG composite with a NBG content of 30 wt.% showed significantly enhanced in vitro bioactivity and cellular response compared to those of the pure PCL. (C) 2012 Elsevier B.V. All rights reserved.
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Collections - Graduate School > Department of Bioengineering > 1. Journal Articles
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