Effect of testosterone undecanoate on hematological profiles, blood lipid and viscosity and plasma testosterone level in castrated rabbits
DC Field | Value | Language |
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dc.contributor.author | Zhao, Chen | - |
dc.contributor.author | Moon, Du Geon | - |
dc.contributor.author | Park, Jong Kwan | - |
dc.date.accessioned | 2021-09-06T03:04:42Z | - |
dc.date.available | 2021-09-06T03:04:42Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 1911-6470 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103628 | - |
dc.description.abstract | Objective: The association between testosterone replacement therapy and cardiovascular risk remains controversial. Blood viscosity is a known individual risk factor for cardiovascular disease mortality. The objective of the present study was to investigate the effects of the long-acting injectable testosterone undecanoate (TU) on risk factors of cardiovascular disease. Methods: In total, 24 male New Zealand white rabbits (2.5 kg) were randomly divided into 3 groups of 8. Group 1 was used as control. Group 2 was castrated bilaterally and Group 3 was administrated with 6 mg/kg of TU at day 1 and 6 weeks after castration. Whole blood viscosity, total plasma testosterone, hemoglobin (Hb), hematocrit (Hct), fibrinogen (FBN), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were measured at baseline, 6 weeks and 18 weeks. Results: In the control group, whole blood viscosity and FBN were significantly increased at 6 and 18 weeks. Castration significantly increased the levels of TC, TG, HDL-C and LDL-C, but decreased Hct and Hb. In the TU injection group, whole blood viscosity was markedly decreased in all share rates, whereas the FBN level was increased. Hb and Hct showed a tendency for higher concentration at 6 weeks. Conclusions: Long-acting injectable TU provides another reliable treatment option for testosterone replacement therapy. Moreover, the patients may receive additional beneficial effect in lowered whole blood viscosity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CANADIAN UROLOGICAL ASSOCIATION | - |
dc.title | Effect of testosterone undecanoate on hematological profiles, blood lipid and viscosity and plasma testosterone level in castrated rabbits | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Moon, Du Geon | - |
dc.identifier.doi | 10.5489/cuaj.507 | - |
dc.identifier.wosid | 000209410000008 | - |
dc.identifier.bibliographicCitation | CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL, v.7, no.3-4, pp.E221 - E225 | - |
dc.relation.isPartOf | CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL | - |
dc.citation.title | CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL | - |
dc.citation.volume | 7 | - |
dc.citation.number | 3-4 | - |
dc.citation.startPage | E221 | - |
dc.citation.endPage | E225 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
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