Effect of testosterone undecanoate on hematological profiles, blood lipid and viscosity and plasma testosterone level in castrated rabbits
- Authors
- Zhao, Chen; Moon, Du Geon; Park, Jong Kwan
- Issue Date
- 4월-2013
- Publisher
- CANADIAN UROLOGICAL ASSOCIATION
- Citation
- CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL, v.7, no.3-4, pp.E221 - E225
- Indexed
- SCIE
SCOPUS
- Journal Title
- CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
- Volume
- 7
- Number
- 3-4
- Start Page
- E221
- End Page
- E225
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103628
- DOI
- 10.5489/cuaj.507
- ISSN
- 1911-6470
- Abstract
- Objective: The association between testosterone replacement therapy and cardiovascular risk remains controversial. Blood viscosity is a known individual risk factor for cardiovascular disease mortality. The objective of the present study was to investigate the effects of the long-acting injectable testosterone undecanoate (TU) on risk factors of cardiovascular disease. Methods: In total, 24 male New Zealand white rabbits (2.5 kg) were randomly divided into 3 groups of 8. Group 1 was used as control. Group 2 was castrated bilaterally and Group 3 was administrated with 6 mg/kg of TU at day 1 and 6 weeks after castration. Whole blood viscosity, total plasma testosterone, hemoglobin (Hb), hematocrit (Hct), fibrinogen (FBN), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were measured at baseline, 6 weeks and 18 weeks. Results: In the control group, whole blood viscosity and FBN were significantly increased at 6 and 18 weeks. Castration significantly increased the levels of TC, TG, HDL-C and LDL-C, but decreased Hct and Hb. In the TU injection group, whole blood viscosity was markedly decreased in all share rates, whereas the FBN level was increased. Hb and Hct showed a tendency for higher concentration at 6 weeks. Conclusions: Long-acting injectable TU provides another reliable treatment option for testosterone replacement therapy. Moreover, the patients may receive additional beneficial effect in lowered whole blood viscosity.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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