Bergamot Essential Oil Differentially Modulates Intracellular Ca2+ Levels in Vascular Endothelial and Smooth Muscle Cells: A New Finding Seen With Fura-2
- Authors
- You, Ji H.; Kang, Purum; Min, Sun Seek; Seol, Geun Hee
- Issue Date
- 4월-2013
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- bergamot essential oil; linalyl acetate; intracellular Ca2+; vascular endothelial cells; vascular smooth muscle cells
- Citation
- JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, v.61, no.4, pp.324 - 328
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Volume
- 61
- Number
- 4
- Start Page
- 324
- End Page
- 328
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103638
- DOI
- 10.1097/FJC.0b013e3182834681
- ISSN
- 0160-2446
- Abstract
- In this study, we compared the effect of the essential oil of Citrus bergamia Risso [bergamot, bergamot essential oil (BEO)] on the intracellular Ca2+ levels in vascular endothelial (EA) and mouse vascular smooth muscle (MOVAS) cells, using the fura-2 fluorescence technique. BEO caused an initial transient increase in intracellular Ca2+ concentration ([Ca2+](i)) in EA cells, followed by a decrease, whereas it induced a sustained increase in [Ca2+](i) in MOVAS cells. Linalyl acetate (LA) as a major component of BEO-induced [Ca2+](i) mobilization was similar to BEO in EA cells. The increase of [Ca2+](i) by LA was higher in EA cells than in MOVAS cells. [Ca2+](i) rise induced by extracellular Ca2+ application was significantly blocked by BEO or LA in EA cells but not in MOVAS cells, suggesting that BEO and LA block Ca2+ influx in EA cells. The present results suggest that BEO and LA differentially modulate intracellular Ca2+ levels in vascular endothelial and smooth muscle cells. In addition, blockade of Ca2+ influx by BEO and LA in EA cells may explain the protective effects of BEO on endothelial dysfunction associated with cardiovascular disease.
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