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Role of severity and gender in the association between late-life depression and all-cause mortality

Authors
Jeong, Hyun-GhangLee, Jung JaeLee, Seok BumPark, Joon HyukHuh, YoonseokHan, Ji WonKim, Tae HuiChin, Ho JunKim, Ki Woong
Issue Date
4월-2013
Publisher
CAMBRIDGE UNIV PRESS
Keywords
late-life depression; major depressive disorder; minor depressive disorder; subsyndromal depression; mortality; gender
Citation
INTERNATIONAL PSYCHOGERIATRICS, v.25, no.4, pp.677 - 684
Indexed
SCIE
SSCI
SCOPUS
Journal Title
INTERNATIONAL PSYCHOGERIATRICS
Volume
25
Number
4
Start Page
677
End Page
684
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/103641
DOI
10.1017/S1041610212002190
ISSN
1041-6102
Abstract
Background: Mortality associated with depression may be influenced by severity of depression and gender. We investigated the differential impacts on all-cause mortality of late-life depression by the type of depression (major depressive disorder, MDD; minor depressive disorder, MnDD; subsyndromal depression, SSD) and gender after adjusting comorbid conditions in the randomly sampled elderly. Methods: One thousand community-dwelling elderly individuals were enrolled. Standardized face-to-face clinical interviews, neurological examination, and physical examination were conducted to diagnose depressive disorders and comorbid cognitive disorders. Depressive disorders were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria and SSD to study-specific operational criteria. Five-year survivals were compared between groups using Cox proportional hazards models. Results: By the end of 2010, 174 subjects (17.4%) died. Depressive disorder (p = 0.001) and its interaction term with gender (p < 0.001) were significant in predicting five-year survival. MDD was an independent risk factor for mortality in men (hazard ratio = 3.65, 95% confidence interval = 1.67-7.96) whereas MnDD and SSD were not when other risk factors were adjusted. Conclusions: MDD may directly confer the risk of mortality in elderly men whereas non-major depression may be just an indicator of increased mortality in both genders.
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