Deep subcortical infarct burden in relation to apolipoprotein B/AI ratio in patients with intracranial atherosclerotic stenosis

Abstract

Background and purpose Pre-existing brain infarct (PBI), frequently seen on magnetic resonance imaging and usually silent, is recognized as a risk factor for future stroke. Increased apolipoprotein B (apoB)/apoAI ratio is known to be a risk predictor of ischaemic stroke and is associated with intracranial atherosclerotic stenosis (ICAS). However, little is known about the association of apoB/apoAI ratio with PBI. Methods A total of 522 statin-/fibrate-naive Korean patients, who experienced acute ischaemic stroke, were categorized into three groups: ICAS (n=254), extracranial (n=51), and no cerebral atherosclerotic stenosis (n=217). We explored the association between apoB/apoAI ratio and PBI lesions according to atherosclerosis type (ICAS, ECAS, and NCAS), PBI location (deep subcortical [ds-PBI] versus hemispheric [h-PBI]), and symptomatic PBI (s-PBI) which was relevant to a prior clinical stroke event. Results Pre-existing brain infarct(+) patients showed a higher apoB/apoAI ratio than PBI() patients (0.81 +/- 0.28 vs. 0.72 +/- 0.23, P<0.001). In ICAS group, patients with higher apoB/apoAI ratio quartiles had more PBIs, ds-PBIs, and s-PBIs (P=0.020, P=0.025, and P=0.001, respectively). With multivariable analyses, the highest apoB/apoAI ratio quartile was associated with PBI (OR, 2.56; 95% CI, 1.394.73), ds-PBI (2.48; 1.334.62), and advanced (3) ds-PBIs (2.68; 1.275.63) in ICAS group, but not with h-PBI. s-PBI had a doseresponse relationship with apoB/apoAI ratio quartiles (6.18; 1.3129.13 for the second; 5.34; 1.0626.83 for the third; and 12.17; 2.5059.19 for the fourth quartile), when referenced to the first quartile. Conclusion ApoB/apoAI ratio is associated with asymptomatic deep subcortical ischaemic burden as well as with symptomatic lesion in patients with ICAS.