Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Deep subcortical infarct burden in relation to apolipoprotein B/AI ratio in patients with intracranial atherosclerotic stenosis

Authors
Park, J. -H.Hong, K. -S.Lee, J.Kim, Y. -J.Song, P.
Issue Date
4월-2013
Publisher
WILEY-BLACKWELL
Keywords
apolipoprotein AI; apolipoprotein B; atherosclerosis; brain infarction; intracranial
Citation
EUROPEAN JOURNAL OF NEUROLOGY, v.20, no.4, pp.671 - 680
Indexed
SCIE
SCOPUS
Journal Title
EUROPEAN JOURNAL OF NEUROLOGY
Volume
20
Number
4
Start Page
671
End Page
680
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/103675
DOI
10.1111/ene.12021
ISSN
1351-5101
Abstract
Background and purpose Pre-existing brain infarct (PBI), frequently seen on magnetic resonance imaging and usually silent, is recognized as a risk factor for future stroke. Increased apolipoprotein B (apoB)/apoAI ratio is known to be a risk predictor of ischaemic stroke and is associated with intracranial atherosclerotic stenosis (ICAS). However, little is known about the association of apoB/apoAI ratio with PBI. Methods A total of 522 statin-/fibrate-naive Korean patients, who experienced acute ischaemic stroke, were categorized into three groups: ICAS (n=254), extracranial (n=51), and no cerebral atherosclerotic stenosis (n=217). We explored the association between apoB/apoAI ratio and PBI lesions according to atherosclerosis type (ICAS, ECAS, and NCAS), PBI location (deep subcortical [ds-PBI] versus hemispheric [h-PBI]), and symptomatic PBI (s-PBI) which was relevant to a prior clinical stroke event. Results Pre-existing brain infarct(+) patients showed a higher apoB/apoAI ratio than PBI() patients (0.81 +/- 0.28 vs. 0.72 +/- 0.23, P<0.001). In ICAS group, patients with higher apoB/apoAI ratio quartiles had more PBIs, ds-PBIs, and s-PBIs (P=0.020, P=0.025, and P=0.001, respectively). With multivariable analyses, the highest apoB/apoAI ratio quartile was associated with PBI (OR, 2.56; 95% CI, 1.394.73), ds-PBI (2.48; 1.334.62), and advanced (3) ds-PBIs (2.68; 1.275.63) in ICAS group, but not with h-PBI. s-PBI had a doseresponse relationship with apoB/apoAI ratio quartiles (6.18; 1.3129.13 for the second; 5.34; 1.0626.83 for the third; and 12.17; 2.5059.19 for the fourth quartile), when referenced to the first quartile. Conclusion ApoB/apoAI ratio is associated with asymptomatic deep subcortical ischaemic burden as well as with symptomatic lesion in patients with ICAS.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE