Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering
DC Field | Value | Language |
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dc.contributor.author | Jun, Shin-Hee | - |
dc.contributor.author | Lee, Eun-Jung | - |
dc.contributor.author | Jang, Tae-Sik | - |
dc.contributor.author | Kim, Hyoun-Ee | - |
dc.contributor.author | Jang, Jun-Hyeog | - |
dc.contributor.author | Koh, Young-Hag | - |
dc.date.accessioned | 2021-09-06T04:00:24Z | - |
dc.date.available | 2021-09-06T04:00:24Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0957-4530 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/103876 | - |
dc.description.abstract | In this study, a silica xerogel-chitosan hybrid is utilized as a coating material to incorporate bone morphogenic protein-2 (BMP-2) on a porous hydroxyapatite (HA) scaffold for bone tissue engineering. BMP-2 is known as a therapeutic agent for improving bone regeneration and repair. Silica xerogel-chitosan hybrids have been used for the delivery of a growth factor as well as osteoconductive coatings. The biological properties of the hybrid coating incorporated with BMP-2 were evaluated in terms of the BMP-2 release behavior, osteoblastic cellular responses and in vivo performance. BMP-2 was continuously released from the hybrid coating layer on the porous HA scaffold for up to 6 weeks. The hybrid coating containing BMP-2 showed significantly enhanced osteoblastic cell responses in comparison with the hybrid coating and HA substrate. Consequently, new bone formation was significantly increased within the hybrid coating containing BMP-2. These results reveal that the hybrid coating containing BMP-2 has the potential to be used as a bone implant, whose osteogenic properties are promoted by the release of BMP-2 in a controlled manner for a prolonged period of time. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | PORE CHANNELS | - |
dc.subject | IN-VIVO | - |
dc.subject | POROSITY | - |
dc.subject | SURFACE | - |
dc.title | Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Young-Hag | - |
dc.identifier.doi | 10.1007/s10856-012-4822-0 | - |
dc.identifier.scopusid | 2-s2.0-84876411058 | - |
dc.identifier.wosid | 000316018700020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v.24, no.3, pp.773 - 782 | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | - |
dc.citation.title | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | - |
dc.citation.volume | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 773 | - |
dc.citation.endPage | 782 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | PORE CHANNELS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | POROSITY | - |
dc.subject.keywordPlus | SURFACE | - |
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