Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering
- Authors
- Jun, Shin-Hee; Lee, Eun-Jung; Jang, Tae-Sik; Kim, Hyoun-Ee; Jang, Jun-Hyeog; Koh, Young-Hag
- Issue Date
- 3월-2013
- Publisher
- SPRINGER
- Citation
- JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v.24, no.3, pp.773 - 782
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
- Volume
- 24
- Number
- 3
- Start Page
- 773
- End Page
- 782
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103876
- DOI
- 10.1007/s10856-012-4822-0
- ISSN
- 0957-4530
- Abstract
- In this study, a silica xerogel-chitosan hybrid is utilized as a coating material to incorporate bone morphogenic protein-2 (BMP-2) on a porous hydroxyapatite (HA) scaffold for bone tissue engineering. BMP-2 is known as a therapeutic agent for improving bone regeneration and repair. Silica xerogel-chitosan hybrids have been used for the delivery of a growth factor as well as osteoconductive coatings. The biological properties of the hybrid coating incorporated with BMP-2 were evaluated in terms of the BMP-2 release behavior, osteoblastic cellular responses and in vivo performance. BMP-2 was continuously released from the hybrid coating layer on the porous HA scaffold for up to 6 weeks. The hybrid coating containing BMP-2 showed significantly enhanced osteoblastic cell responses in comparison with the hybrid coating and HA substrate. Consequently, new bone formation was significantly increased within the hybrid coating containing BMP-2. These results reveal that the hybrid coating containing BMP-2 has the potential to be used as a bone implant, whose osteogenic properties are promoted by the release of BMP-2 in a controlled manner for a prolonged period of time.
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Collections - Graduate School > Department of Bioengineering > 1. Journal Articles
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