Protective effect of 70% ethanolic extract of Lindera obtusiloba Blume on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats
- Authors
- Hong, Chung-Oui; Rhee, Chae Hong; Won, Nam-Hee; Choi, Hee-Don; Lee, Kwang-Won
- Issue Date
- 3월-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Lindera obtusiloba; Hepatotoxicity; Oxidative stress; tert-butyl hydroperoxide; Quercitrin; Afzelin
- Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.53, pp.214 - 220
- Indexed
- SCIE
SCOPUS
- Journal Title
- FOOD AND CHEMICAL TOXICOLOGY
- Volume
- 53
- Start Page
- 214
- End Page
- 220
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103905
- DOI
- 10.1016/j.fct.2012.11.032
- ISSN
- 0278-6915
- Abstract
- Lindera obtusiloba Blume, a native plant of East Asia, has traditionally been used as a folk medicine for liver disease. We studied the in vitro antioxidant and in vivo hepatoprotective activities of a 70% ethanolic extract of L. obtusiloba (LOE) containing 62.9% quercitrin and 22.0% afzelin. LOE prevented tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in HepG2 cells. Along with its high antioxidant potency in vitro, our animal study confirmed that pretreatment with LOE (500 or 2000 mg/kg) for 7 days prior to a single dose of t-BHP (i.p.: 0.5 mmol/kg) significantly lowered the serum levels of alanine and aspartate aminotransferases. In addition, glutathione levels were increased in the liver, and lipid peroxidation levels were decreased in a dose-dependent manner. The histopathological examinations of rat livers showed that LOE significantly reduced the incidence of liver lesions induced by t-BHP. Therefore, we concluded that LOE has merit as a potent candidate to protect the liver against oxidative damage. (C) 2012 Elsevier Ltd. All rights reserved.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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