Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia
- Authors
- Rhee, Chin Kook; Min, Kyung Hoon; Yim, Nam Yeol; Lee, Ji Eun; Lee, Na Rae; Chung, Man Pyo; Jeon, Kyeongman
- Issue Date
- 2월-2013
- Publisher
- EUROPEAN RESPIRATORY SOC JOURNALS LTD
- Keywords
- Acute disease; pulmonary eosinophilia; respiratory insufficiency; smoking; treatment outcome
- Citation
- EUROPEAN RESPIRATORY JOURNAL, v.41, no.2, pp.402 - 409
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN RESPIRATORY JOURNAL
- Volume
- 41
- Number
- 2
- Start Page
- 402
- End Page
- 409
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104110
- DOI
- 10.1183/09031936.00221811
- ISSN
- 0903-1936
- Abstract
- The clinical characteristics and optimal duration of corticosteroid treatment for acute eosinophilic pneumonia (AEP) have not been fully evaluated. This was a retrospective study of prospectively collected data from 137 patients with AEP, treated with standardised protocol, to clarify the clinical characteristics and compare the efficacies of 2 weeks versus 4 weeks of corticosteroid treatment for AEP. The majority of the patients altered their smoking habits within a median (interquartile range) of 17 (13-26) days prior to development of AEP. 80 (58%) patients presented with acute respiratory failure. A total of 127 (92%) patients were treated with corticosteroids: 4 weeks, n=42; 2 weeks, n=85. Major symptoms were resolved in 3 days and the severity of respiratory failure was inversely correlated with clinical outcomes. After adjusting for differences in baseline characteristics between the groups, the differences in adjusted mean (95% confidence interval) for resolution of dyspnoea and disappearance of all symptoms were 0.57 (-0.71-1.86) and -0.04 (-1.91-1.83) days, respectively. The difference in adjusted proportion of resolution of radiological abnormalities was 6.92% (-8.19-22.02). In conclusion, the duration of corticosteroid treatment could be shortened to 2 weeks, even in patients with respiratory failure.
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