Relationship between disease-specific structures of amyloid fibrils and their mechanical properties
- Authors
- Yoon, Gwonchan; Kim, Young Kab; Eom, Kilho; Na, Sungsoo
- Issue Date
- 7-1월-2013
- Publisher
- AMER INST PHYSICS
- Citation
- APPLIED PHYSICS LETTERS, v.102, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- APPLIED PHYSICS LETTERS
- Volume
- 102
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104219
- DOI
- 10.1063/1.4774296
- ISSN
- 0003-6951
- Abstract
- It has recently been reported that the mechanical behavior of prion nanofibrils may play a critical role in expression of neurodegenerative diseases. In this work, we have studied the mechanical behavior of HET-s prion nanofibrils using an elastic network model. We have shown that the mechanical properties of prion nanofibrils formed as left-handed beta-helices are different from those of non-prion nanofibrils formed as right-handed beta-helices. In particular, the bending behavior of prion nanofibrils depends on the length of the nanofibril and that the bending rigidity of the prion nanofibril is larger than that of the non-prion nanofibril. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4774296]
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Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
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