Clinicopathological Significance of Plasminogen Activator Inhibitor-1 Promoter 4G/5G Polymorphism in Breast Cancer: A Meta-analysis
- Authors
- Lee, Ju-Han; Kim, Younghye; Choi, Jung-Woo; Kim, Young-Sik
- Issue Date
- 1월-2013
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- PAI-1; Polymorphism; Breast cancer; Meta-analysis
- Citation
- ARCHIVES OF MEDICAL RESEARCH, v.44, no.1, pp.39 - 45
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARCHIVES OF MEDICAL RESEARCH
- Volume
- 44
- Number
- 1
- Start Page
- 39
- End Page
- 45
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/104310
- DOI
- 10.1016/j.arcmed.2012.12.002
- ISSN
- 0188-4409
- Abstract
- Background and Aims. Plasminogen activator inhibitor type 1 (PAI-1) is associated with poor prognosis in breast cancer. Transcriptional expression of the PAI-1 can be controlled by PAI-1 promoter 4G/5G polymorphism. However, the significance of PAI-1 promoter 4G/5G polymorphism in breast cancer patients is contentious. To address this controversy, we conducted a meta-analysis for the relationships between PAI-1 promoter polymorphism and clinicopathological characteristics of breast cancer. Methods. Relevant published studies were identified using a search of PubMed, Embase, and the ISI Web of Science. The effect sizes of PAI-1 promoter 4G/5G polymorphism on breast cancer risk, lymph node metastasis, histologic grade, and overall survival were calculated by odds ratio (OR) or hazard ratio. The effect sizes were combined using a random-effects model. Results. Individuals with 4G/4G genotype had a higher risk of breast cancer than those with the combined 4G/5G and 5G/5G genotypes (OR = 1.388; p = 0.031). Breast cancer patients with the 5G/5G genotype displayed lymph node metastasis more than patients with either the combined other genotypes (OR = 1.495; p = 0.027) or with the 4G/4G genotype (OR = 1.623; p = 0.018). However, the PAI-1 promoter 4G/5G polymorphism was not associated with histological grade or overall survival. Conclusions. PAI-1 promoter 4G/5G polymorphism is associated with a relatively increased risk of breast cancer development and lymph node metastasis. (C) 2013 IMSS. Published by Elsevier Inc.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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