Clear Cell Carcinomas of the Ovary: A Multi-Institutional Study of 129 Cases in Korea With Prognostic Significance of Emi1 and Galectin-3
DC Field | Value | Language |
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dc.contributor.author | Min, Kyueng-Whan | - |
dc.contributor.author | Park, Moon Hyang | - |
dc.contributor.author | Hong, Sung Ran | - |
dc.contributor.author | Lee, Heejung | - |
dc.contributor.author | Kwon, Sun Young | - |
dc.contributor.author | Hong, Sook Hee | - |
dc.contributor.author | Joo, Hee Jae | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | An, Hee Jung | - |
dc.contributor.author | Suh, Kwang Sun | - |
dc.contributor.author | Oh, Hoon Kyu | - |
dc.contributor.author | Yoo, Chong Woo | - |
dc.contributor.author | Kim, Mi Jin | - |
dc.contributor.author | Chang, Hee Kyung | - |
dc.contributor.author | Jun, Sun Young | - |
dc.contributor.author | Yoon, Hye Kyoung | - |
dc.contributor.author | Chang, Eun Deok | - |
dc.contributor.author | Kim, Dong Won | - |
dc.contributor.author | Kim, Insun | - |
dc.date.accessioned | 2021-09-06T05:46:09Z | - |
dc.date.available | 2021-09-06T05:46:09Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 0277-1691 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/104337 | - |
dc.description.abstract | Accurate diagnosis of ovarian clear cell carcinoma (CCC) is important because of its poor prognosis with chemoresistance and a high recurrent rate. The clinicopathologic characteristics and prognostic significance of the cell cycle regulator [ early mitotic inhibitor-1 (Emi1)] and galactoside-binding protein (Galectin-3) were evaluated. Among 155 CCCs from 18 hospitals in Korea between 1995 and 2006, 129 pure CCCs were selected with consensus using immunohistochemical stains for hepatocyte nuclear factor-1 beta, Wilms' tumor protein, and estrogen receptor. The expressions of Emi1, Galectin-3, p53, and Ki-67 labeling index were analyzed with clinicopathologic parameters and the patient's survival. The mean age of the patients was 49.6 yr; the tumors were bilateral in 10.9%, and the average size was 12 cm. Adenofibromatous component was found in 7%, and endometriosis in 48.1% of the cases. Psammoma body was seen in 16.3%. Disease-free survival and overall survival rates were 78.3% and 79.1%, respectively. The International Federation of Obstetrics and Gynecology (FIGO) stage was the most important prognostic indicator. Emi1 expression (>5%) was seen in 23.3% of CCCs, and associated with high FIGO grades and poor overall survival (P<0.05). High Galectin-3 (>= 80%) expression was seen in 59.7% of CCCs, and associated with FIGO stages III and IV, and high Ki-67 labeling index. High Ki-67 labeling index (>= 50%) and p53 expression (>= 50%) were seen in 27.1% and 18.6% of CCCs, respectively, but there was no clinicopathologic and prognostic significance. On the basis of the fact that the expression of Emi1 in CCC was correlated with a high histologic grade and worse overall survival, target therapy using inhibitors of Emi1 may be tried in the management of CCC patients with Emi1 expression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ANAPHASE PROMOTING COMPLEX/CYCLOSOME | - |
dc.subject | UNIVERSAL GRADING SYSTEM | - |
dc.subject | CLINICAL CHARACTERISTICS | - |
dc.subject | BINDING LECTIN | - |
dc.subject | P53 | - |
dc.subject | EXPRESSION | - |
dc.subject | ENDOMETRIOSIS | - |
dc.subject | CANCER | - |
dc.subject | TUMORS | - |
dc.subject | OVEREXPRESSION | - |
dc.title | Clear Cell Carcinomas of the Ovary: A Multi-Institutional Study of 129 Cases in Korea With Prognostic Significance of Emi1 and Galectin-3 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Insun | - |
dc.identifier.doi | 10.1097/PGP.0b013e31825554e9 | - |
dc.identifier.scopusid | 2-s2.0-84871659005 | - |
dc.identifier.wosid | 000312562100002 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, v.32, no.1, pp.3 - 14 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 3 | - |
dc.citation.endPage | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | ANAPHASE PROMOTING COMPLEX/CYCLOSOME | - |
dc.subject.keywordPlus | UNIVERSAL GRADING SYSTEM | - |
dc.subject.keywordPlus | CLINICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | BINDING LECTIN | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ENDOMETRIOSIS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordAuthor | Clear cell carcinoma | - |
dc.subject.keywordAuthor | Emi1 protein | - |
dc.subject.keywordAuthor | Galectin-3 | - |
dc.subject.keywordAuthor | p53 antigen | - |
dc.subject.keywordAuthor | Ki-67 antigen | - |
dc.subject.keywordAuthor | Ovarian cancer | - |
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